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Active Recombinant Human PTGS2 protein, His-tagged

Cat.No. : PTGS2-30H
Product Overview : Recombinant Human PTGS2 fused with His tag at N-terminal was expressed in Insect cells.
  • Specification
  • Gene Information
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Description : COX-2 catalyzes the conversion of arachidonic acid to prostaglandin H2 (the first step in the biosynthesis of prostaglandins, thromboxanes, and prostacyclins). It is the inducible form of cyclooxygenase, induced by phorbol esters, lipopolysaccharides, and cytokines. COX-2 is upregulated in the neovasculature of malignant tumors. Inhibition of COX-2 with nonsteroidal anti-inflammatory drugs (NSAIDs) is associated with decreased tumor growth.
Source : Insect cells
Species : Human
Tag : His
Form : Solution in 80 mM Tris-HCl, pH 8.0 with 0.1% TWEEN® 20 and 300 μM diethyldithiocarbamate and 10% glycerol.
Bio-activity : > 8000 units/mg
Molecular Mass : dimer subunit mol wt 70-74 kDa
Purity : >70% (SDS-PAGE)
Unit Definition : One unit will consume 1.0 nanomole of oxygen per minute at pH 8 at 37 centigrade.
Storage : Store at −70 centigrade
Shipping : dry ice
Gene Name : PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) [ Homo sapiens ]
Official Symbol : PTGS2
Synonyms : PTGS2; prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase); prostaglandin G/H synthase 2; COX2; PHS II; PGH synthase 2; cyclooxygenase 2b; prostaglandin H2 synthase 2; COX-2; PHS-2; PGG/HS; PGHS-2; hCox-2; GRIPGHS;
Gene ID : 5743
mRNA Refseq : NM_000963
Protein Refseq : NP_000954
MIM : 600262
UniProt ID : P35354
Chromosome Location : 1q25.2-q25.3
Pathway : Arachidonic acid metabolism, organism-specific biosystem; Arachidonic acid metabolism, conserved biosystem; Biological oxidations, organism-specific biosystem; C-MYB transcription factor network, organism-specific biosystem; COX reactions, organism-specific biosystem; Calcineurin-regulated NFAT-dependent transcription in lymphocytes, organism-specific biosystem; Calcium signaling in the CD4+ TCR pathway, organism-specific biosystem;
Function : enzyme binding; heme binding; heme binding; lipid binding; metal ion binding; oxidoreductase activity; oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen; peroxidase activity; peroxidase activity; peroxidase activity; prostaglandin-endoperoxide synthase activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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