Recombinant Human RAN (G19V/Q69L) Protein

• Cat.No.: RAN-718H
• Product Overview: Recombinant Human RAN protein (NM_006325, G19V/Q69L) was expressed in E. coli .

Specification

• Description: Ran belongs to the Ras superfamily of GTP binding proteins. It acts in cellular processes such as nuclear transport, mitotic spindle assembly, and post-mitotic nuclear assembly. The mutation Q69L abolishes GTP hydrolysis. The mutation G19V results in a gain-of-function mutant that is not, however, sensitive to the exchange factor RCC1. Protein preparation is 19% GDP-loaded, measured by HPLC.
• Source: E. coli
• Species: Human
• Form: 50 mM KH2PO4/K2HPO4 pH 7.0, 6.5 mM DTE, 150 mM KCl and 5 mM MgCl2
• Molecular Mass: 24.0 kDa
• Protein length: 216 amino acids
• Purity: > 95 % (SDS-PAGE)
• Storage: Store at -80 centigrade, avoid freeze/thaw cycles.

Gene Information

• Gene Name: RAN RAN, member RAS oncogene family [ Homo sapiens ]
• Official Symbol: RAN
• Synonyms: TC4; Gsp1; ARA24
• Gene ID: 5901
• mRNA Refseq: NM_006325.3
• Protein Refseq: NP_006316.1
• MIM: 601179
• UniProt ID: P62826