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Active Recombinant Human RHOT1 protein, His-tagged

Cat.No. : RHOT1-261H
Product Overview : Recombinant Human RHOT1(Ile186 - Thr591) fused with His tag at N-terminal was expressed in E. coli.
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Description : Mitochondrial Rho GTPase 1 (also known as Miro1 or Rhot1) is a membrane associated GTPase with a predicted molecular weight of 71 kDa. Miro1 has been reported to directly associate with the KIF5 motor protein, allowing mitochondria to move along microtubules. A number of publications have identifed Miro1 as an in vivo substrate for the E3 Ubiquitin ligase Parkin (encoded by the PARK2 gene), an essential component of the cellular machinery that participates in the removal of damaged mitochondria. This protein is useful as an in vitro substrate for activated recombinant Parkin enzyme.
Source : E. coli
Species : Human
Tag : His
Form : X mg/ml (X μM) in 50 mM HEPES, 200 mM NaCl, 2 mM TCEP
Bio-activity : Reaction Conditions will be optimized for each specific application. In a 50 μl reaction containing 1 μM activated Parkin E3 ligase, 1 μM His6-Miro1 is fully converted to Ubiquitinated forms in 60 minutes.
Molecular Mass : Predicted Molecular Mass: 50 kDa
Purity : >90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Storage : Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -70 centigrade as supplied.
3 months, -70 centigrade under sterile conditions after opening.
Gene Name : RHOT1 ras homolog family member T1 [ Homo sapiens ]
Official Symbol : RHOT1
Synonyms : RHOT1; ras homolog family member T1; ARHT1, ras homolog gene family, member T1; mitochondrial Rho GTPase 1; FLJ11040; MIRO 1; mitochondrial Rho (MIRO) GTPase 1; hMiro-1; mitochondrial Rho 1; ras homolog gene family, member T1; rac-GTP binding protein-like protein; rac-GTP-binding protein-like protein; ARHT1; MIRO1; MIRO-1; FLJ12633;
Gene ID : 55288
mRNA Refseq : NM_001033566
Protein Refseq : NP_001028738
MIM : 613888
UniProt ID : Q8IXI2

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Are there any specific inhibitors or activators of RHOT1 protein currently being developed for clinical use? 12/04/2022

Researchers are exploring the development of small molecule inhibitors or activators targeting RHOT1 protein for potential clinical applications in the future.

How is the RHOT1 protein related to neurodegenerative diseases? 03/29/2021

Dysregulation of RHOT1 protein has been implicated in neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease.

Can mutations in the RHOT1 gene lead to mitochondrial dysfunction? 11/08/2020

Yes, mutations in the RHOT1 gene can disrupt mitochondrial dynamics and lead to mitochondrial dysfunction, which may contribute to the development of various diseases.

What are the cellular functions of RHOT1 protein? 09/21/2018

RHOT1 protein is involved in the maintenance of mitochondrial morphology, regulation of mitochondrial fission and fusion, and control of mitochondrial dynamics.

Are there any potential therapeutic targets related to the RHOT1 protein? 02/03/2018

RHOT1 protein and its associated pathways are being investigated as potential therapeutic targets for neurodegenerative diseases and other disorders characterized by mitochondrial dysfunction.

Customer Reviews (3)

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Reviews
08/25/2022

    This versatility allows me to explore different aspects of my research with confidence and accuracy.

    01/10/2020

      the RHOT1 protein's excellent functionality makes it highly suitable for various trial applications.

      06/17/2018

        Whether I am investigating enzymatic activity, studying protein-protein interactions, or testing its role in signaling pathways, the RHOT1 protein consistently performs exceptionally well.

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