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Active Recombinant Human ROCK2 protein, GST-tagged

Cat.No. : ROCK2-26H
Product Overview : Recombinant Human ROCK2(5-554 aa) fused with GST tag at N-terminal was expressed in Insect cells.
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Description : ROCK2 is a ubiquitously expressed serine/threonine kinase localized in the nucleus that regulates cytokinesis, smooth muscle contraction, the formation of actin stress fibers and focal adhesions, and the activation of the c-fos serum response element. ROCK2 is an immediate downstream target of the small GTPase RhoA. ROCK2 may play a pivotal role in cardiovascular diseases such as vasospastic angina, ischemic stroke, and heart failure. Inhibition of ROCKs by statins or other selective inhibitors leads to the upregulation and activation of endothelial nitric oxide synthase (eNOS) and reduction of vascular inflammation and atherosclerosis.
Source : Insect cells
Species : Human
Tag : GST
Form : 50mM Tris-HCl, pH 7.5, 150mM NaCl, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol.
Bio-activity : 575 nmol/min/mg
Molecular Mass : ~88 kDa
Purity : >90%
Applications : Kinase Assay, Western Blot
Stability : 1 year at - 70 centigrade from the date of shipment
Storage : Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Gene Name : ROCK2 Rho-associated, coiled-coil containing protein kinase 2 [ Homo sapiens ]
Official Symbol : ROCK2
Synonyms : ROCK2; Rho-associated, coiled-coil containing protein kinase 2; rho-associated protein kinase 2; p164 ROCK-2; rho-associated, coiled-coil-containing protein kinase II; ROCK-II; KIAA0619;
Gene ID : 9475
mRNA Refseq : NM_004850
Protein Refseq : NP_004841
MIM : 604002
UniProt ID : O75116
Chromosome Location : 2p24
Pathway : Axon guidance, organism-specific biosystem; Axon guidance, conserved biosystem; Axon guidance, organism-specific biosystem; Chemokine signaling pathway, organism-specific biosystem; Chemokine signaling pathway, conserved biosystem; Developmental Biology, organism-specific biosystem; Focal Adhesion, organism-specific biosystem;
Function : ATP binding; metal ion binding; nucleotide binding; protein binding; protein serine/threonine kinase activity; structural molecule activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Discuss the role of ROCK2 in smooth muscle contraction and vascular tone. 03/24/2022

ROCK2 is a key regulator of smooth muscle contraction, influencing vascular tone by phosphorylating myosin light chain and promoting actin-myosin interaction.

Describe the molecular crosstalk between ROCK2 and other signaling pathways. 08/07/2021

ROCK2 interacts with various signaling pathways, including Wnt, PI3K/Akt, and MAPK pathways, forming a network that regulates cell survival, proliferation, and differentiation.

How does ROCK2 contribute to the regulation of cell cycle progression? 12/04/2020

ROCK2 can influence the cell cycle by regulating cyclin-dependent kinase activity and promoting the phosphorylation of proteins involved in cell cycle checkpoints.

What are the implications of ROCK2 in cell migration and invasion? 03/18/2019

ROCK2 is involved in the regulation of cell migration and invasion by controlling actin dynamics and focal adhesion turnover, influencing processes like metastasis in cancer.

Discuss the role of ROCK2 in the regulation of the actin cytoskeleton. 06/11/2018

ROCK2 phosphorylates various downstream targets, such as myosin light chain, leading to actin-myosin contraction and the reorganization of the actin cytoskeleton.

Customer Reviews (3)

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Reviews
08/19/2021

    Swift and hassle-free delivery ensured our experiments stayed on track.

    01/13/2020

      Efficient customer service provided valuable insights for our decision-making.

      07/06/2019

        Reliable and precise—this recombined protein never disappoints.

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