Recombinant Human SELE protein, Fc-tagged
Cat.No. : | SELE-661H |
Product Overview : | Recombinant Human SELE protein (Trp22-Phe556), fused to human IgG1 Fc tag at C-terminus, was expressed in human 293 cells (HEK293). |
- Specification
- Gene Information
- Related Products
Description : | E-Selectin is also known as CD62 antigen-like family member E (CD62E), endothelial-leukocyte adhesion molecule 1 (ELAM-1), or leukocyte-endothelial cell adhesion molecule 2 (LECAM2), a member of the Selectin family, is a 107-115 kDa cell surface glycoprotein. It is transiently expressed on vascular endothelial cells in response to IL-1β and TNFα. E selectin has a cassette structure: an N-terminal, C-type lectin domain, an EGF (epidermal-growth-factor)-like domain, 6 Sushi domain (SCR repeat) units, a transmembrane domain (TM) and an intracellular cytoplasmic tail (cyto). During inflammation, E-selectin plays an important part in recruiting leukocytes to the site of injury. The local release of cytokines IL-1 and TNF-α by damaged cells induces the over-expression of E-selectin on endothelial cells of nearby blood vessels. E-selectin mediates the adhesion of tumor cells to endothelial cells, by binding to E-selectin ligands expressed by neutrophils, monocytes, eosinophils, memory-effector T-like lymphocytes, natural killer cells or cancer cells. Furthermore, a number of studies have reported that levels of E-Selectin may be elevated in subjects with a variety of pathological conditions. |
Source : | HEK293 |
Species : | Human |
Tag : | human IgG1 Fc |
Form : | Lyophilized from 0.22 um filtered solution in 50 mM Tris, 100 mM Glycine, pH7.5, 10% trehalose. |
Molecular Mass : | The protein has a calculated MW of 84.8 kDa. The protein migrates as 150 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. |
Protein length : | 535 |
Endotoxin : | Less than 1.0 EU per ug by the LAL method. |
Purity : | >95% as determined by SDS-PAGE. |
Storage : | For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower. Please avoid repeated freeze-thaw cycles. This product is stable after storage at: -20 centigrade to -70 centigrade for 12 months in lyophilized state; -70 centigrade for 3 months under sterile conditions after reconstitution. |
Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents. |
Gene Name : | SELE |
Official Symbol : | SELE |
Synonyms : | SELE; selectin E; ELAM, ELAM1, endothelial adhesion molecule 1; E-selectin; CD62E; ESEL; ELAM-1; endothelial adhesion molecule 1; CD62 antigen-like family member E; endothelial leukocyte adhesion molecule 1; leukocyte endothelial cell adhesion molecule 2; leukocyte-endothelial cell adhesion molecule 2; ELAM; ELAM1; LECAM2 |
Gene ID : | 6401 |
mRNA Refseq : | NM_000450 |
Protein Refseq : | NP_000441 |
MIM : | 131210 |
UniProt ID : | P16581 |
Products Types
◆ Recombinant Protein | ||
Sele-6390R | Recombinant Rat Sele Protein, His (Fc)-Avi-tagged | +Inquiry |
SELE-05H | Active Recombinant Human SELE Protein, His-tagged | +Inquiry |
Sele-2048M | Recombinant Mouse Sele Protein, His-tagged | +Inquiry |
SELE-209H | Recombinant Human SELE Protein, His-tagged | +Inquiry |
SELE-800P | Recombinant Pig SELE Protein (23-429 aa), GST-tagged | +Inquiry |
◆ Lysates | ||
SELE-960RCL | Recombinant Rat SELE cell lysate | +Inquiry |
SELE-2992HCL | Recombinant Human SELE cell lysate | +Inquiry |
SELE-1099CCL | Recombinant Cynomolgus SELE cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionSome diagnostic tests can measure SELE levels in the blood, providing insights into the inflammatory status of an individual.
Emerging research suggests a potential role of SELE in cancer metastasis, making it a target for investigation in cancer therapy.
Genetic variations can influence SELE expression, contributing to individual differences in inflammatory responses.
SELE binds to specific receptors on immune cells, facilitating their adhesion to endothelial cells and promoting their migration to inflammatory sites.
Yes, drugs designed to modulate SELE activity are being explored as potential anti-inflammatory agents.
Customer Reviews (3)
Write a reviewWith its remarkable purity and reliability, coupled with the manufacturer's excellent technical support, this protein is a crucial asset in addressing my scientific inquiries and advancing my research goals.
In addition to its outstanding quality, the SELE Protein exhibits exceptional stability during storage and usage.
Its ability to maintain structural integrity and stability ensures accurate imaging, enabling me to gain deeper insights into the three-dimensional organization and interactions of the proteins under investigation.
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