Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

Recombinant Human SERPINE1 Protein, MYC/DDK-tagged

Cat.No. : SERPINE1-1003H
Product Overview : Recombinant human SERPINE1 protein, fused to MYC/DDK tag at C-terminus, was expressed in HEK293.
  • Specification
  • Gene Information
  • Related Products
Description : This gene encodes a member of the serine proteinase inhibitor (serpin) superfamily. This member is the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), and hence is an inhibitor of fibrinolysis. Defects in this gene are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency), and high concentrations of the gene product are associated with thrombophilia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009].
Source : HEK293
Species : Human
Tag : MYC/DDK
Form : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
Molecular Mass : 42.7 kDa
Purity : >50 ug/mL as determined by microplate BCA method
Concentration : >50 ug/mL as determined by microplate BCA method
Gene Name : SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 [ Homo sapiens ]
Official Symbol : SERPINE1
Synonyms : PAI; PAI-1; PAI1; PLANH1
Gene ID : 5054
mRNA Refseq : NM_000602
Protein Refseq : NP_000593
MIM : 173360
UniProt ID : P05121

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

Inquiry

  • Q&As
  • Reviews

Q&As (6)

Ask a question
Are there any gene polymorphisms or mutations in SERPINE1, and how do these mutations affect function? 11/13/2022

Yes, there are some genetic polymorphisms and mutations SERPINE1. These mutations may affect the structure and function of the protein they encode, which in turn affects their physiological and pathological effects. Some mutations have been shown to be involved in thrombosis and tumorigenesis.

What are the potential therapeutic applications of SERPINE1 inhibitors or activators? 10/03/2022

Inhibitors or activators targeting SERPINE1 may have potential applications for the treatment of a variety of diseases, including tumors, thrombosis, neurological diseases, etc. At present, there are some small molecule inhibitors for SERPINE1 that have entered the clinical trial stage.

How does SERPINE1 affect apoptosis and repair of nerve cells? 07/17/2022

SERPINE1 may prevent neuronal apoptosis by inhibiting serine protease activity, and may promote neuronal cell repair by regulating the activity of cytokines and growth factors.

What are the new directions or breakthroughs in the study of SERPINE1 and its related molecular mechanisms in future research? 02/18/2022

The research on SERPINE1 and its related molecular mechanisms will continue to explore its mechanism of action in human physiological and pathological processes. Future research may uncover new modes of action, new modulators, and new therapeutic applications.

Are there other inhibitors or activators in the SERPINE1? 04/03/2021

In addition to being an inhibitor of serine proteases, SERPINE1 may also be affected by other inhibitors or activators. These inhibitors or activators may work by modulating the activity or expression levels of the SERPINE1.

How is SERPINE1 related to Alzheimer's disease? 09/07/2020

In Alzheimer's disease, SERPINE1 may influence the onset and progression of the disease by regulating β amyloid deposition and neuroinflammatory processes.

Customer Reviews (3)

Write a review
Reviews
06/02/2022

    It has a wide range of applications in the field of scientific research and is suitable for a variety of experimental design and research purposes.

    07/16/2021

      When used for experiments, the experimental conditions and results are highly repeatable.

      02/28/2021

        SERPINE1 has good solubility and is easy to operate and purify.

        Ask a Question for All SERPINE1 Products

        Required fields are marked with *

        My Review for All SERPINE1 Products

        Required fields are marked with *

        0

        Inquiry Basket

        cartIcon
        logo

        FOLLOW US

        Terms and Conditions        Privacy Policy

        Copyright © 2024 Creative BioMart. All Rights Reserved.

        Contact Us

        • /

        Stay Updated on the Latest Bioscience Trends