Active Recombinant Human SETD1A protein, GST-tagged
| Cat.No. : | SETD1A-198H |
| Product Overview : | Recombinant Human SETD1A(1418-end) fused with GST tag at N-terminal was expressed in Insect cells. |
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| Description : | As a member of the mixed lineage leukemia (MLL) family of histone methyltransferase, it specifically methylates 'Lys-4' of histone H3, when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. |
| Source : | Insect cells |
| Species : | Human |
| Tag : | GST |
| Form : | 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol. |
| Bio-activity : | 500 nmol/min/mg |
| Molecular Mass : | 61 kDa |
| Protein length : | 1418-end |
| Purity : | >70% |
| Applications : | Methyltransferase Assay |
| Stability : | 1 year at -70 centigrade from the date of shipment |
| Storage : | Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
| Concentration : | 0.1μg/μl |
| Publication : |
Uhrf1 regulates active transcriptional marks at bivalent domains in pluripotent stem cells through Setd1a (2018)
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| Gene Name : | SETD1A SET domain containing 1A [ Homo sapiens ] |
| Official Symbol : | SETD1A |
| Synonyms : | SETD1A; SET domain containing 1A; histone-lysine N-methyltransferase SETD1A; KIAA0339; KMT2F; Set1; hSET1A; lysine N-methyltransferase 2F; SET domain-containing protein 1A; set1/Ash2 histone methyltransferase complex subunit SET1; Set1A; |
| Gene ID : | 9739 |
| mRNA Refseq : | NM_014712 |
| Protein Refseq : | NP_055527 |
| MIM : | 611052 |
| UniProt ID : | O15047 |
| Chromosome Location : | 16p11.2 |
| Pathway : | Lysine degradation, organism-specific biosystem; Lysine degradation, conserved biosystem; |
| Function : | RNA binding; histone methyltransferase activity (H3-K4 specific); methyltransferase activity; nucleotide binding; protein binding; transferase activity; |
Products Types
| ◆ Recombinant Protein | ||
| SETD1A-184H | Recombinant Human SET1A Complex Protein, His/GST-tagged | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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