"SETD2" Related Products

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Recombinant Human SETD2 protein, GST-tagged, Active

Cat.No.: SETD2-199H
Product Overview: Recombinant Human SETD2(1425-1717 aa) fused with GST tag at N-terminal was expressed in Insect cells.
Description: As a member of the mixed lineage leukemia (MLL) family of histone methyltransferase, SETD2 specifically tri-methylates 'Lys-36' of histone H3 (H3K36me3) using dimethylated 'Lys-36' (H3K36me2) as substrate. The main enzyme generating H3K36me3, a specific tag for epigenetic transcriptional activation.
Source: Insect cells
Species: Human
Tag : GST
Form: 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Bio-activity: 250 nmol/min/mg
Molecular Mass: 61 kDa
Purity: >70%
Applications: Methyltransferase Assay
Stability: 1 year at -70 centigrade from the date of shipment
Storage: Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Concentration: 0.1μg/μl
Gene Name: SETD2 SET domain containing 2 [ Homo sapiens ]
Official Symbol: SETD2
Synonyms: SETD2; SET domain containing 2; histone-lysine N-methyltransferase SETD2; FLJ23184; HIF 1; HYPB; KIAA1732; KMT3A; huntingtin yeast partner B; lysine N-methyltransferase 3A; huntingtin interacting protein 1; huntingtin-interacting protein B; SET2; HIF-1; H
Gene ID: 29072
mRNA Refseq: NM_014159
Protein Refseq: NP_054878
MIM: 612778
UniProt ID: Q9BYW2
Chromosome Location: 3p21.31
Pathway: Lysine degradation, organism-specific biosystem; Lysine degradation, conserved biosystem;
Function: DNA binding; histone-lysine N-methyltransferase activity; methyltransferase activity; oxidoreductase activity; protein binding; transferase activity; transition metal ion binding;

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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