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Active Recombinant Human SETD2 protein, GST-tagged

Cat.No. : SETD2-199H
Product Overview : Recombinant Human SETD2(1425-1717 aa) fused with GST tag at N-terminal was expressed in Insect cells.
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  • Gene Information
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Description : As a member of the mixed lineage leukemia (MLL) family of histone methyltransferase, SETD2 specifically tri-methylates 'Lys-36' of histone H3 (H3K36me3) using dimethylated 'Lys-36' (H3K36me2) as substrate. The main enzyme generating H3K36me3, a specific tag for epigenetic transcriptional activation.
Source : Insect cells
Species : Human
Tag : GST
Form : 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Bio-activity : 250 nmol/min/mg
Molecular Mass : 61 kDa
Purity : >70%
Applications : Methyltransferase Assay
Stability : 1 year at -70 centigrade from the date of shipment
Storage : Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Concentration : 0.1μg/μl
Gene Name : SETD2 SET domain containing 2 [ Homo sapiens ]
Official Symbol : SETD2
Synonyms : SETD2; SET domain containing 2; histone-lysine N-methyltransferase SETD2; FLJ23184; HIF 1; HYPB; KIAA1732; KMT3A; huntingtin yeast partner B; lysine N-methyltransferase 3A; huntingtin interacting protein 1; huntingtin-interacting protein B; SET2; HIF-1; H
Gene ID : 29072
mRNA Refseq : NM_014159
Protein Refseq : NP_054878
MIM : 612778
UniProt ID : Q9BYW2
Chromosome Location : 3p21.31
Pathway : Lysine degradation, organism-specific biosystem; Lysine degradation, conserved biosystem;
Function : DNA binding; histone-lysine N-methyltransferase activity; methyltransferase activity; oxidoreductase activity; protein binding; transferase activity; transition metal ion binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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