Recombinant Human SHBG protein, His-tagged
Cat.No. : | SHBG-504H |
- Specification
- Gene Information
- Related Products
Product overview : | Recombinant Human SHBG (P04278) aa. (Gly224~His388) fused with His tag was produced in HEK293F cells. |
Description : | This gene encodes a steroid binding protein that was first described as a plasma protein secreted by the liver but is now thought to participate in the regulation of steroid responses. The encoded protein transports androgens and estrogens in the blood, binding each steroid molecule as a dimer formed from identical or nearly identical monomers. Polymorphisms in this gene have been associated with polycystic ovary syndrome and type 2 diabetes mellitus. Alternative splicing results in multiple transcript variants. |
Source : | HEK293F |
Species : | Human |
Tag : | His |
Form : | Freeze-dried powder |
Molecular Mass : | Predicted Molecular Mass: 19.3kDa; Accurate Molecular Mass: 19kDa as determined by SDS-PAGE reducing conditions. |
Protein length : | Gly224~His388 |
Endotoxin : | <1.0EU per 1ug (determined by the LAL method) |
Purity : | > 60% |
Characteristic : | Isoelectric point is 6.6. |
Applications : | SDS-PAGE; WB; ELISA; IP; CoIP; EMSA; Reporter Assays; Purification; Amine Reactive Labeling |
Stability : | The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition. |
Storage : | Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months. |
Concentration : | 200ug/mL |
Storage buffer : | 20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 5% Trehalose and Proclin300. |
Reconstitution : | Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex |
Gene Name : | SHBG sex hormone binding globulin [ Homo sapiens (human) ] |
Official Symbol : | SHBG |
Synonyms : | SHBG; sex hormone binding globulin; ABP; SBP; TEBG; sex hormone-binding globulin; sex steroid-binding protein; testis-specific androgen-binding protein; testosterone-binding beta-globulin; testosterone-estradiol-binding globulin; testosterone-estrogen-binding globulin |
Gene ID : | 6462 |
mRNA Refseq : | NM_001040.4 |
Protein Refseq : | NP_001031.2 |
UniProt ID : | P04278 |
Products Types
◆ Recombinant Protein | ||
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Shbg-5853M | Recombinant Mouse Shbg Protein, Myc/DDK-tagged | +Inquiry |
SHBG-5048R | Recombinant Rat SHBG Protein, His (Fc)-Avi-tagged | +Inquiry |
SHBG-8140M | Recombinant Mouse SHBG Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Native Protein | ||
SHBG-8259H | Native Human Serum Sex Hormone Binding Globulin | +Inquiry |
SHBG-5519H | Native Human Sex Hormone-Binding Globulin | +Inquiry |
SHBG-30637TH | Native Human SHBG protein | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionSHBG interacts with cell surface receptors, influencing cellular responses to sex hormones.
SHBG levels are used to assess free testosterone levels, helping diagnose hormonal imbalances.
Factors influencing SHBG levels include age, sex, hormonal balance, and certain medical conditions.
Abnormally high SHBG can reduce free testosterone, potentially leading to hypogonadism, while low SHBG can increase free testosterone, possibly contributing to conditions like polycystic ovary syndrome (PCOS) and insulin resistance.
SHBG is predominantly produced in the liver.
SHBG binds and transports sex hormones, particularly testosterone and estradiol, in the bloodstream.
By binding sex hormones, SHBG controls their free, bioavailable forms and regulates their activity.
Customer Reviews (3)
Write a reviewVery satisfied, worked perfectly.
Fast shipping, product perfect.
Excellent results in assay.
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