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Recombinant Human SHBG protein, His-tagged

Cat.No. : SHBG-504H
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  • Gene Information
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Product overview : Recombinant Human SHBG (P04278) aa. (Gly224~His388) fused with His tag was produced in HEK293F cells.
Description : This gene encodes a steroid binding protein that was first described as a plasma protein secreted by the liver but is now thought to participate in the regulation of steroid responses. The encoded protein transports androgens and estrogens in the blood, binding each steroid molecule as a dimer formed from identical or nearly identical monomers. Polymorphisms in this gene have been associated with polycystic ovary syndrome and type 2 diabetes mellitus. Alternative splicing results in multiple transcript variants.
Source : HEK293F
Species : Human
Tag : His
Form : Freeze-dried powder
Molecular Mass : Predicted Molecular Mass: 19.3kDa; Accurate Molecular Mass: 19kDa as determined by SDS-PAGE reducing conditions.
Protein length : Gly224~His388
Endotoxin : <1.0EU per 1ug (determined by the LAL method)
Purity : > 60%
Characteristic : Isoelectric point is 6.6.
Applications : SDS-PAGE; WB; ELISA; IP; CoIP; EMSA; Reporter Assays; Purification; Amine Reactive Labeling
Stability : The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Storage : Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
Concentration : 200ug/mL
Storage buffer : 20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 5% Trehalose and Proclin300.
Reconstitution : Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex
Gene Name : SHBG sex hormone binding globulin [ Homo sapiens (human) ]
Official Symbol : SHBG
Synonyms : SHBG; sex hormone binding globulin; ABP; SBP; TEBG; sex hormone-binding globulin; sex steroid-binding protein; testis-specific androgen-binding protein; testosterone-binding beta-globulin; testosterone-estradiol-binding globulin; testosterone-estrogen-binding globulin
Gene ID : 6462
mRNA Refseq : NM_001040.4
Protein Refseq : NP_001031.2
UniProt ID : P04278

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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How does SHBG interact with other proteins and receptors in the body? 12/07/2022

SHBG interacts with cell surface receptors, influencing cellular responses to sex hormones.

How is SHBG used as a diagnostic marker in clinical settings? 08/21/2022

SHBG levels are used to assess free testosterone levels, helping diagnose hormonal imbalances.

What factors can influence the levels of SHBG in the bloodstream? 04/16/2022

Factors influencing SHBG levels include age, sex, hormonal balance, and certain medical conditions.

What are the implications of abnormally high or low levels of SHBG? 03/19/2022

Abnormally high SHBG can reduce free testosterone, potentially leading to hypogonadism, while low SHBG can increase free testosterone, possibly contributing to conditions like polycystic ovary syndrome (PCOS) and insulin resistance.

In which organs or tissues is SHBG predominantly produced? 09/06/2021

SHBG is predominantly produced in the liver.

What is the primary biological role of Sex Hormone-Binding Globulin (SHBG) in the body? 01/23/2020

SHBG binds and transports sex hormones, particularly testosterone and estradiol, in the bloodstream.

How does SHBG regulate the bioavailability of sex hormones? 01/08/2020

By binding sex hormones, SHBG controls their free, bioavailable forms and regulates their activity.

Customer Reviews (3)

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Reviews
10/27/2022

    Very satisfied, worked perfectly.

    09/15/2021

      Fast shipping, product perfect.

      04/06/2021

        Excellent results in assay.

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