Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

Recombinant Human SLAMF7 protein, His-tagged

Cat.No. : SLAMF7-200H
Product Overview : Recombinant human SLAMF7, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
  • Specification
  • Gene Information
  • Related Products
Description : SLAMF7, also known as SLAM family member 7, is a single-pass type 1 membrane protein and a member of the CS2 family of cell surface receptors. Isoform 1 of this protein mediates NK cell activation through a SH2D1A-independent extracellular signal-regulated ERK-mediated pathway. It may play a role in lymphocyte adhesion. SLAMF7 can exert activating of inhibitory influences on cells of the immune system depending on cellular context and the availability of effector proteins.
Source : Insect cell
Species : Human
Tag : His
Form : Liquid. In Phosphate Buffered Saline (pH 7.4) containing 10% glycerol.
Molecular Mass : 23.4kDa (212aa)28-40KDa (SDS–PAGE under reducing conditions.)
AA Sequence : SGPVKELVGS VGGAVTFPLK SKVKQVDSIV WTFNTTPLVT IQPEGGTIIV TQNRNRERVD FPDGGYSLKL SKLKKNDSGI YYVGIYSSSL QQPSTQEYVL HVYEHLSKPK VTMGLQSNKN GTCVTNLTCC MEHGEEDVIY TWKALGQAAN ESHNGSILPI SWRWGESDMT FICVARNPVSRNFSSPILAR KLCEGAADDP DSSMLEHHHH HH
Endotoxin : < 1.0 EU per 1 microgram of protein (determined by LAL method)
Purity : > 95% by SDS – PAGE
Storage : Can be stored at +4 centigrade short term (1-2 weeks). For long term storage, aliquot and store at -20 centigrade or -70 centigrade. Avoid repeated freezing and thawing cycles.
Concentration : 0.5mg/ml (determined by Absorbance at 280nm)
Gene Name : SLAMF7 SLAM family member 7 [ Homo sapiens ]
Official Symbol : SLAMF7
Synonyms : SLAMF7; SLAM family member 7; 19A; CD319; CRACC; CS1; protein 19A; CD2 subset 1; 19A24 protein; membrane protein FOAP-12; CD2-like receptor activating cytotoxic cells; CD2-like receptor-activating cytotoxic cells; novel LY9 (lymphocyte antigen 9) like protein;
Gene ID : 57823
mRNA Refseq : NM_021181
Protein Refseq : NP_067004
MIM : 606625
UniProt ID : Q9NQ25
Chromosome Location : 1q23.1-q24.1
Function : receptor activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

Inquiry

  • Q&As
  • Reviews

Q&As (6)

Ask a question
What is the mechanism by which SLAMF7 protein regulates immune responses? 10/13/2022

SLAMF7 protein is involved in regulating immune cell activation, proliferation, and transmission of background signals by binding to activating ligands, such as CD319, thereby influencing the immune response.

What is the potential of combining SLAMF7 protein with immunotherapy? 05/02/2022

By combining with immunotherapy, such as anti-PD-1 antibodies, the immune response can be further enhanced and the anti-tumor effect can be improved. The study of SLAMF7 protein provides a new direction for the development of combinatorial therapeutic strategies.

In which tissues or cells is SLAMF7 protein expressed? 12/13/2021

This protein is mainly expressed in the immune system, including immune cells such as plasma cells, NK cells, and activated T cells.

Does the SLAMF7 protein have a similar role in other types of cancer? 11/14/2020

The role of SLAMF7 protein in other types of cancer is unclear, and further research is needed to determine its potential role in other cancers.

Does SLAMF7 protein have potential in the treatment of multiple myeloma? 05/20/2020

Yes, the SLAMF7 protein has been shown to be a potential therapeutic target. A monoclonal antibody drug targeting SLAMF7 protein (Elotuzumab) has been developed for the treatment of multiple myeloma.

What is the function of SLAMF7 protein in multiple myeloma? 12/11/2019

SLAMF7 protein interacts with NK cells in multiple myeloma and plays a role in inhibiting and controlling tumor growth by activating the anti-tumor activity of NK cells.

Customer Reviews (3)

Write a review
Reviews
07/28/2023

    It has a high solubility and can be easily prepared at the desired concentration.

    07/26/2021

      It was found to be well active and could effectively perform the required biological activity experiments.

      04/15/2020

        It was observed that SLAMF7 had good crystallinity, which was conducive to crystallography research.

        Ask a Question for All SLAMF7 Products

        Required fields are marked with *

        My Review for All SLAMF7 Products

        Required fields are marked with *

        0

        Inquiry Basket

        cartIcon
        logo

        FOLLOW US

        Terms and Conditions        Privacy Policy

        Copyright © 2024 Creative BioMart. All Rights Reserved.

        Contact Us

        • /

        Stay Updated on the Latest Bioscience Trends