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Recombinant Human SLC2A4 protein, GST-tagged

Cat.No. : SLC2A4-112H
Product Overview : Recombinant Human SLC2A4(1 a.a. - 509 a.a.)fused with GST tag at N-terminal was expressed in Wheat Germ.
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  • Gene Information
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Description : This gene is a member of the solute carrier family 2 (facilitated glucose transporter) family and encodes a protein that functions as an insulin-regulated facilitative glucose transporter. In the absence of insulin, this integral membrane protein is sequestered within the cells of muscle and adipose tissue. Within minutes of insulin stimulation, the protein moves to the cell surface and begins to transport glucose across the cell membrane. Mutations in this gene have been associated with noninsulin-dependent diabetes mellitus (NIDDM).
Source : Wheat Germ
Species : Human
Tag : GST
Form : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Molecular Mass : 81.2 kDa
AA Sequence : MPSGFQQIGSEDGEPPQQRVTGTLV LAVFSAVLGSLQFGYNIGVINAPQK VIEQSYNETWLGRQGPEGPSSIPPG TLTTLWALSVAIFSVGGMISSFLIG IISQWLGRKRAMLVNNVLAVLGGSL MGLANAAASYEMLILGRFLIGAYSG LTSGLVPMYVGEIAPTHLRGALGTL NQLAIVIGILIAQVLGLESLLGTAS LWPLLLGLTVLPALLQLVLLPFCPE SPRYLYIIQNLEGPARKSLKRLTGW ADVSGVLAELKDEKRKLERERPLSL LQLLGSRTHRQPLIIAVVLQLSQQL SGINAVFYYSTSIFETAGVGQPAYA TIGAGVVNTVFTLVSVLLVERAGRR TLHLLGLAGMCGCAILMTVALLLLE RVPAMSYVSIVAIFGFVAFFEIGPG PIPWFIVAELFSQGPRPAAMAVAGF SNWTSNFIIGMGFQYVAEAMGPYVF LLFAVLLLGFFIFTFLRVPETRGRT FDQISAAFHRTPSLLEQEVKPSTEL EYLGPDEND
Applications : Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array
Notes : Best use within three months from the date of receipt of this protein.
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Gene Name : SLC2A4 solute carrier family 2 (facilitated glucose transporter), member 4 [ Homo sapiens ]
Official Symbol : SLC2A4
Synonyms : SLC2A4; solute carrier family 2 (facilitated glucose transporter), member 4; GLUT4; solute carrier family 2, facilitated glucose transporter member 4; GLUT-4; insulin-responsive glucose transporter type 4; glucose transporter type 4, insulin-responsive;
Gene ID : 6517
mRNA Refseq : NM_001042
Protein Refseq : NP_001033
MIM : 138190
UniProt ID : P14672
Chromosome Location : 17p13
Pathway : AMPK signaling, organism-specific biosystem; Adipocytokine signaling pathway, organism-specific biosystem; Adipocytokine signaling pathway, conserved biosystem; Adipogenesis, organism-specific biosystem; Arf6 trafficking events, organism-specific biosystem; Class I PI3K signaling events mediated by Akt, organism-specific biosystem; Developmental Biology, organism-specific biosystem;
Function : D-glucose transmembrane transporter activity; glucose transmembrane transporter activity; protein binding; substrate-specific transmembrane transporter activity;

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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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How does SLC2A4 protein relate to heart health? 02/09/2023

SLC2A4 dysfunction may contribute to impaired glucose metabolism in the heart, potentially impacting cardiac function and increasing the risk of heart disease.

How does exercise affect SLC2A4 protein expression and function? 11/11/2022

Regular exercise can enhance SLC2A4 expression and translocation to the cell membrane, improving glucose uptake and insulin sensitivity.

Can SLC2A4 protein be targeted for therapeutic interventions? 05/07/2020

Yes, SLC2A4 is a potential target for developing drugs to improve glucose uptake and insulin sensitivity in diabetes.

What are the potential implications of SLC2A4 protein in cancer? 08/21/2017

Some studies suggest that SLC2A4 may play a role in the metabolism of cancer cells, and its expression levels could be linked to cancer progression and prognosis.

Can genetic variations in the SLC2A4 gene influence individual response to antidiabetic medications? 02/18/2017

Yes, genetic variations in SLC2A4 may impact how individuals respond to certain antidiabetic medications, such as insulin sensitizers.

Customer Reviews (3)

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Reviews
02/08/2023

    The SLC2A4 protein exhibits outstanding performance in enzyme-linked immunosorbent assays (ELISA).

    11/13/2022

      Its purity and reliability ensure reliable and reproducible results in a variety of research applications.

      07/29/2019

        The protein's reliability and reproducibility in WB ensure accurate analysis of target proteins, while its suitability for electron microscopy structure analysis enables detailed examination of molecular structures.

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