Recombinant Human SMO overexpression lysate
Cat.No. : | SMO-1617HCL |
Product Overview : | Transient overexpression lysate of smoothened homolog (Drosophila) (SMO) was abtained from Human HEK293T cell line. |
- Specification
- Gene Information
- Related Products
Source : | HEK293T |
Species : | Human |
Tag : | Myc/DDK |
Form : | RIPA buffer |
Molecular Mass : | 86.2 kDa |
Usage : | 1 vial of 100 µg gene specific transient over-expression cell lysate in RIPA buffer 1 vial of 100 µg empty vector transfected control cell lysate in RIPA buffer 1 vial of 250ul 2xSDS Sample Buffer (4% SDS, 125mM Tris-HCl pH6.8, 10% Glycerol, 0.002% Bromphenol blue, 100mM DTT) |
Stability : | Lysate samples are stable for 12 months from date of receipt when stored at -20 centigrade. Avoid repeated freeze-thaw cycles. |
Storage : | Lysate samples can be diluted with 2xSDS Sample Buffer provided. After dilution, the protein sample should be aliquoted and stored at -20 centigrade for long term storage. Prior to SDS-PAGE fractionation, boil the lysate for 5 minutes. |
Gene Name : | SMO smoothened, frizzled family receptor [ Homo sapiens ] |
Official Symbol : | SMO |
Synonyms : | SMO; smoothened, frizzled family receptor; SMOH, smoothened (Drosophila) homolog , smoothened homolog (Drosophila) , smoothened, seven transmembrane spanning receptor; smoothened homolog; frizzled family member 11; FZD11; protein Gx; seven transmembrane helix receptor; smoothened, seven transmembrane spanning receptor; Gx; SMOH |
Gene ID : | 6608 |
mRNA Refseq : | NM_005631 |
Protein Refseq : | NP_005622 |
MIM : | 601500 |
UniProt ID : | Q99835 |
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Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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- Reviews
Q&As (5)
Ask a questionAberrant activation of the SMO protein is associated with several types of cancer, including basal cell carcinoma and medulloblastoma. Mutations or overexpression of SMO can lead to uncontrolled cell growth and tumorigenesis.
Yes, researchers are actively investigating the role of SMO protein in various diseases beyond cancer, including neurological disorders and regenerative medicine.
SMO protein modulation can influence stem cell fate decisions, playing a role in processes such as self-renewal and differentiation.
SMO inhibitors are being explored as therapeutic agents in cancer treatment, particularly for tumors driven by abnormal Hedgehog signaling. These inhibitors aim to block the activity of SMO and, consequently, disrupt the downstream signaling cascade.
Clinical trials have shown promise for SMO inhibitors in treating basal cell carcinoma, medulloblastoma, and other cancers with dysregulated Hedgehog signaling.
Customer Reviews (3)
Write a reviewThe manufacturer of SMO protein plays a crucial role in supporting my research endeavors.
The use of SMO protein in my research offers significant advantages in detecting cell death processes and investigating coagulation and thrombosis mechanisms.
Its ability to bind to negatively charged phospholipids, particularly during blood clot formation, has made it invaluable for in vitro and in vivo investigations of hemostatic mechanisms.
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