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Recombinant Human SMO overexpression lysate

Cat.No. : SMO-1617HCL
Product Overview : Transient overexpression lysate of smoothened homolog (Drosophila) (SMO) was abtained from Human HEK293T cell line.
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  • Gene Information
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Source : HEK293T
Species : Human
Tag : Myc/DDK
Form : RIPA buffer
Molecular Mass : 86.2 kDa
Usage : 1 vial of 100 µg gene specific transient over-expression cell lysate in RIPA buffer
1 vial of 100 µg empty vector transfected control cell lysate in RIPA buffer
1 vial of 250ul 2xSDS Sample Buffer (4% SDS, 125mM Tris-HCl pH6.8, 10% Glycerol, 0.002% Bromphenol blue, 100mM DTT)
Stability : Lysate samples are stable for 12 months from date of receipt when stored at -20 centigrade. Avoid repeated freeze-thaw cycles.
Storage : Lysate samples can be diluted with 2xSDS Sample Buffer provided. After dilution, the protein sample should be aliquoted and stored at -20 centigrade for long term storage. Prior to SDS-PAGE fractionation, boil the lysate for 5 minutes.
Gene Name : SMO smoothened, frizzled family receptor [ Homo sapiens ]
Official Symbol : SMO
Synonyms : SMO; smoothened, frizzled family receptor; SMOH, smoothened (Drosophila) homolog , smoothened homolog (Drosophila) , smoothened, seven transmembrane spanning receptor; smoothened homolog; frizzled family member 11; FZD11; protein Gx; seven transmembrane helix receptor; smoothened, seven transmembrane spanning receptor; Gx; SMOH
Gene ID : 6608
mRNA Refseq : NM_005631
Protein Refseq : NP_005622
MIM : 601500
UniProt ID : Q99835

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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How does the dysregulation of SMO protein contribute to cancer development? 07/30/2021

Aberrant activation of the SMO protein is associated with several types of cancer, including basal cell carcinoma and medulloblastoma. Mutations or overexpression of SMO can lead to uncontrolled cell growth and tumorigenesis.

Are there ongoing research efforts to discover new clinical applications for SMO protein modulation? 12/29/2020

Yes, researchers are actively investigating the role of SMO protein in various diseases beyond cancer, including neurological disorders and regenerative medicine.

How does SMO protein modulation impact stem cell behavior and differentiation? 12/04/2020

SMO protein modulation can influence stem cell fate decisions, playing a role in processes such as self-renewal and differentiation.

What are the current clinical applications of SMO inhibitors in cancer treatment? 09/20/2018

SMO inhibitors are being explored as therapeutic agents in cancer treatment, particularly for tumors driven by abnormal Hedgehog signaling. These inhibitors aim to block the activity of SMO and, consequently, disrupt the downstream signaling cascade.

In which cancer types have SMO inhibitors shown promising results in clinical trials? 05/11/2018

Clinical trials have shown promise for SMO inhibitors in treating basal cell carcinoma, medulloblastoma, and other cancers with dysregulated Hedgehog signaling.

Customer Reviews (3)

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Reviews
11/23/2021

    The manufacturer of SMO protein plays a crucial role in supporting my research endeavors.

    11/16/2018

      The use of SMO protein in my research offers significant advantages in detecting cell death processes and investigating coagulation and thrombosis mechanisms.

      08/22/2018

        Its ability to bind to negatively charged phospholipids, particularly during blood clot formation, has made it invaluable for in vitro and in vivo investigations of hemostatic mechanisms.

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