Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

Recombinant Human SMYD2 protein, GST-tagged

Cat.No. : SMYD2-262H
Product Overview : Recombinant Human SMYD2 fused with GST tag at N-terminal was expressed in E. coli.
  • Specification
  • Gene Information
  • Related Products
Description : SMYD2 is a lysine mono-methyltransferase that has been shown to have activity on histone H3, p53 (Lys370), pRB (Lys380) and HSP90 (Lys616). The SMYD2 locus is amplified in lung carcinoma, serous ovarian carcinoma, and pancreatic ductal adenocarcinoma. SMYD2 expression is linked to a variety of cancers. Elevated levels of SMYD2 in esophageal squamous cell carcinoma patients are correlated with lower rates of survival.
Source : E. coli
Species : Human
Tag : GST
Form : In 100mM Tris pH 8.0, 10 mM glutathione and 10% glycerol.
Molecular Mass : 68 kDa
Applications : Recombinant SMYD2, human is useful for histone H3 methylation experiments, enzyme kinetics and inhibitor screening. Use of 1-3 µg SMYD2 per reaction with recombinant histone H3 as a substrate is recommended.
Storage : Stable for six months at -80 centigrade from date of receipt. For best results, aliquot and avoid multiple freeze/thaws.
Concentration : 1 µg/µl
Gene Name : SMYD2 SET and MYND domain containing 2 [ Homo sapiens ]
Official Symbol : SMYD2
Synonyms : SMYD2; SET and MYND domain containing 2; N-lysine methyltransferase SMYD2; HSKM B; KMT3C; ZMYND14; lysine N-methyltransferase 3C; histone methyltransferase SMYD2; zinc finger, MYND domain containing 14; SET and MYND domain-containing protein 2; HSKM-B; MGC119305;
Gene ID : 56950
mRNA Refseq : NM_020197
Protein Refseq : NP_064582
MIM : 610663
UniProt ID : Q9NRG4
Chromosome Location : 1q32.3
Pathway : p53 pathway, organism-specific biosystem;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

Inquiry

  • Q&As
  • Reviews

Q&As (5)

Ask a question
Are there any drugs targeting SMYD2 in the clinical pipeline? 07/30/2020

Investigations into small molecules and inhibitors targeting SMYD2 are underway, with potential applications in cancer and cardiovascular disease treatment.

In what ways can SMYD2 be utilized in the diagnosis of cardiovascular disorders? 06/29/2020

Monitoring SMYD2 levels may provide insights into the progression of cardiovascular diseases, aiding in early diagnosis and treatment.

Can SMYD2 be used as a therapeutic target for neurodegenerative disorders? 03/26/2020

Research suggests that SMYD2 may play a role in neurodegenerative diseases, and exploring its modulation could offer new avenues for therapeutic intervention.

How does SMYD2 influence cellular processes beyond cancer and cardiac diseases? 07/15/2018

SMYD2 is involved in various cellular processes, including cell cycle regulation, DNA repair, and inflammation, making it a versatile protein with potential implications in multiple diseases.

How does SMYD2 contribute to cardiac disease? 10/05/2016

SMYD2 has been linked to cardiac hypertrophy and heart failure, suggesting its potential as a therapeutic target in the context of cardiovascular diseases.

Customer Reviews (3)

Write a review
Reviews
01/16/2018

    Its compatibility with various methodologies further enhances its value as a research tool, making it a go-to choice for investigating SMYD2 protein function and molecular interactions.

    03/20/2017

      The versatility of the SMYD2 protein extends beyond these applications, enabling its use in a wide range of experimental techniques.

      08/31/2016

        the SMYD2 protein stands out for its exceptional quality and its ability to fulfill my experimental requirements.

        Ask a Question for All SMYD2 Products

        Required fields are marked with *

        My Review for All SMYD2 Products

        Required fields are marked with *

        0

        Inquiry Basket

        cartIcon
        logo

        FOLLOW US

        Terms and Conditions        Privacy Policy

        Copyright © 2024 Creative BioMart. All Rights Reserved.

        Contact Us

        • /

        Stay Updated on the Latest Bioscience Trends