Recombinant Human SMYD2 protein, GST-tagged
Cat.No. : | SMYD2-262H |
Product Overview : | Recombinant Human SMYD2 fused with GST tag at N-terminal was expressed in E. coli. |
- Specification
- Gene Information
- Related Products
Description : | SMYD2 is a lysine mono-methyltransferase that has been shown to have activity on histone H3, p53 (Lys370), pRB (Lys380) and HSP90 (Lys616). The SMYD2 locus is amplified in lung carcinoma, serous ovarian carcinoma, and pancreatic ductal adenocarcinoma. SMYD2 expression is linked to a variety of cancers. Elevated levels of SMYD2 in esophageal squamous cell carcinoma patients are correlated with lower rates of survival. |
Source : | E. coli |
Species : | Human |
Tag : | GST |
Form : | In 100mM Tris pH 8.0, 10 mM glutathione and 10% glycerol. |
Molecular Mass : | 68 kDa |
Applications : | Recombinant SMYD2, human is useful for histone H3 methylation experiments, enzyme kinetics and inhibitor screening. Use of 1-3 µg SMYD2 per reaction with recombinant histone H3 as a substrate is recommended. |
Storage : | Stable for six months at -80 centigrade from date of receipt. For best results, aliquot and avoid multiple freeze/thaws. |
Concentration : | 1 µg/µl |
Gene Name : | SMYD2 SET and MYND domain containing 2 [ Homo sapiens ] |
Official Symbol : | SMYD2 |
Synonyms : | SMYD2; SET and MYND domain containing 2; N-lysine methyltransferase SMYD2; HSKM B; KMT3C; ZMYND14; lysine N-methyltransferase 3C; histone methyltransferase SMYD2; zinc finger, MYND domain containing 14; SET and MYND domain-containing protein 2; HSKM-B; MGC119305; |
Gene ID : | 56950 |
mRNA Refseq : | NM_020197 |
Protein Refseq : | NP_064582 |
MIM : | 610663 |
UniProt ID : | Q9NRG4 |
Chromosome Location : | 1q32.3 |
Pathway : | p53 pathway, organism-specific biosystem; |
Products Types
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SMYD2-049H | Active Recombinant Human SMYD2 Protein, His/SUMO-tagged | +Inquiry |
SMYD2-8507M | Recombinant Mouse SMYD2 Protein, His (Fc)-Avi-tagged | +Inquiry |
SMYD2-2063H | Recombinant Human SMYD2 Protein, MYC/DDK-tagged | +Inquiry |
◆ Lysates | ||
SMYD2-705HCL | Recombinant Human SMYD2 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionInvestigations into small molecules and inhibitors targeting SMYD2 are underway, with potential applications in cancer and cardiovascular disease treatment.
Monitoring SMYD2 levels may provide insights into the progression of cardiovascular diseases, aiding in early diagnosis and treatment.
Research suggests that SMYD2 may play a role in neurodegenerative diseases, and exploring its modulation could offer new avenues for therapeutic intervention.
SMYD2 is involved in various cellular processes, including cell cycle regulation, DNA repair, and inflammation, making it a versatile protein with potential implications in multiple diseases.
SMYD2 has been linked to cardiac hypertrophy and heart failure, suggesting its potential as a therapeutic target in the context of cardiovascular diseases.
Customer Reviews (3)
Write a reviewIts compatibility with various methodologies further enhances its value as a research tool, making it a go-to choice for investigating SMYD2 protein function and molecular interactions.
The versatility of the SMYD2 protein extends beyond these applications, enabling its use in a wide range of experimental techniques.
the SMYD2 protein stands out for its exceptional quality and its ability to fulfill my experimental requirements.
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