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Recombinant Human SRSF1 protein, His-tagged

Cat.No. : SRSF1-5264H
Product Overview : Recombinant Human SRSF1(1-248aa) fused with His tag at C-terminal was expressed in Insect cells.
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Description : SRSF1, also known as Serine/arginine-rich splicing factor 1, is a member of the arginine/serine-rich splicing factor protein family, and functions in both constitutive and alternative pre-mRNA splicing. This protein binds to pre-mRNA transcripts and components of the spliceosome, and can either activate or repress splicing depending on the location of the pre-mRNA binding site. The protein's ability to activate splicing is regulated by phosphorylation and interactions with other splicing factor associated proteins. In addition to being involved in the splicing process, it also mediates post-splicing activities, such as mRNA nuclear export and translation.
Source : Insect cells
Species : Human
Tag : His
Form : Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 100mM KCl, 1mM DTT, 0.2mM EDTA, 40% Glycerol
Molecular Mass : 28.5kDa (254aa) 28-40KDa (SDS-PAGE under reducing conditions.)
AA Sequence : MSGGGVIRGP AGNNDCRIYV GNLPPDIRTK DIEDVFYKYG AIRDIDLKNR RGGPPFAFVE FEDPRDAEDA VYGRDGYDYD GYRLRVEFPRSGRGTGRGGG GGGGGGAPRG RYGPPSRRSE NRVVVSGLPP SGSWQDLKDH MREAGDVCYA DVYRDGTGVV EFVRKEDMTY AVRKLDNTKFRSHEGETAYI RVKVDGPRSP SYGRSRSRSR SRSRSRSRSN SRSRSYSPRR SRGSPRYSPR HSRSRSRTHH HHHH
Endotoxin : < 1.0 EU per 1 microgram of protein (determined by LAL method)
Purity : > 95% by SDS - PAGE
Storage : Can be stored at +4 centigrade short term (1-2 weeks). For long term storage, aliquot and store at -20 centigrade or -70 centigrade. Avoid repeated freezing and thawing cycles.
Concentration : 0.25mg/ml (determined by Bradford Assay)
Publication :
SRPK1/2 and PP1α exert opposite functions by modulating SRSF1-guided MKNK2 alternative splicing in colon adenocarcinoma (2021)
Gene Name : SRSF1 serine/arginine-rich splicing factor 1 [ Homo sapiens ]
Official Symbol : SRSF1
Synonyms : SRSF1; serine/arginine-rich splicing factor 1; SFRS1, splicing factor, arginine/serine rich 1; alternate splicing factor; ASF; MGC5228; pre mRNA splicing factor SF2; P33 subunit; SF2; SF2p33; splicing factor 2; SR splicing factor 1; SRp30a; ASF-1; alternative-splicing factor 1; splicing factor, arginine/serine-rich 1; pre-mRNA-splicing factor SF2, P33 subunit; SFRS1; FLJ53078;
Gene ID : 6426
mRNA Refseq : NM_006924
Protein Refseq : NP_008855
MIM : 600812
UniProt ID : Q07955
Chromosome Location : 17q22
Pathway : Cleavage of Growing Transcript in the Termination Region, organism-specific biosystem; Gene Expression, organism-specific biosystem; Herpes simplex infection, organism-specific biosystem; Herpes simplex infection, conserved biosystem; Processing of Capped Intron-Containing Pre-mRNA, organism-specific biosystem; RNA Polymerase II Transcription, organism-specific biosystem; RNA Polymerase II Transcription Termination, organism-specific biosystem;
Function : RNA binding; RS domain binding; nucleotide binding; protein binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Are there any clinical trials targeting SRSF1? 03/20/2022

While there are no approved therapies specifically targeting SRSF1, preclinical studies are investigating its potential as a therapeutic target.

Can SRSF1 be used as a biomarker for cancer? 01/12/2022

Studies suggest that SRSF1 expression levels could potentially serve as a biomarker for cancer diagnosis and prognosis.

Is SRSF1 involved in other diseases besides cancer? 08/01/2020

Yes, SRSF1 has also been implicated in neurodegenerative diseases, such as spinal muscular atrophy.

How does SRSF1 impact pre-mRNA splicing? 03/21/2019

SRSF1 regulates alternative splicing by binding to specific RNA sequences and influencing splice site selection.

How does SRSF1 interact with other proteins in the cell? 01/17/2016

SRSF1 interacts with other splicing factors and signaling proteins to regulate gene expression and cellular functions.

Customer Reviews (3)

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03/21/2023

    Their commitment to providing technical support is unparalleled, and their expertise can prove invaluable in navigating any challenges or troubleshooting that may arise during my experiments.

    07/17/2021

      This commitment to staying at the forefront of research translates directly to the quality and performance of the SRSF1 protein in my trials.

      03/17/2021

        They monitor the latest advancements in the field and incorporate new findings into the production and characterization of the protein.

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