Recombinant Human SSRP1 Protein, His-tagged

• Cat.No.: SSRP1-638H
• Product Overview: Recombinant Human SSRP1(Glu6~Pro246) fused with His tag at N-terminal was expressed in E. coli.

Specification

• Description: The protein encoded by this gene is a subunit of a heterodimer that, along with SUPT16H, forms chromatin transcriptional elongation factor FACT. FACT interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT and cisplatin-damaged DNA may be crucial to the anticancer mechanism of cisplatin. This encoded protein contains a high mobility group box which most likely constitutes the structure recognition element for cisplatin-modified DNA. This protein also functions as a co-activator of the transcriptional activator p63. An alternatively spliced transcript variant of this gene has been described, but its full-length nature is not known.
• Source: E. coli
• Species: Human
• Tag: His
• Form: PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
• Molecular Mass: 31.2kDa
• Identity: Reconstitute in PBS or others
• Protein length: Glu6~Pro246
• Endotoxin: <1.0EU per 1µg (determined by the LAL method)
• Purity: > 95%
• Applications: Positive Control; Immunogen; SDS-PAGE; WB.
  If bio-activity of the protein is needed, please check active protein
• Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
• Reconstitution: Reconstitute in PBS or others

Gene Information

• Gene Name: SSRP1 structure specific recognition protein 1 [ Homo sapiens ]
• Official Symbol: SSRP1
• Synonyms: SSRP1; structure specific recognition protein 1; FACT complex subunit SSRP1; facilitates chromatin remodeling 80 kDa subunit; FACT80; hSSRP1; FACTp80; cisplatin-DNA SSRP; FACT 80 kDa subunit; high mobility group box; structure-specific recognition protein 1; recombination signal sequence recognition protein 1; facilitates chromatin transcription complex subunit SSRP1; facilitates chromatin transcription complex 80 kDa subunit; chromatin-specific transcription elongation factor 80 kDa subunit; FACT; T160
• Gene ID: 6749
• mRNA Refseq: NM_003146
• Protein Refseq: NP_003137
• MIM: 604328
• UniProt ID: Q08945