Recombinant Human TEAD2 protein, His/Sumo-tagged

• Cat.No.: TEAD2-34H
• Product Overview: Recombinant Human TEAD2(94-447aa) fused with His/Sumo tag at N-terminal was expressed in E. coli.

Specification

• Description: Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3'). May be involved in the gene regulation of neural development. Binds to the M-CAT motif.
• Source: E. coli
• Species: Human
• Tag: His/Sumo
• Form: Tris-based buffer, 50% glycerol
• Molecular Mass: 55.29kDa
• Protein length: 94-447aa
• AA Sequence: TRTRKQVSSHIQVLARRKSREIQSK LKDQVSKDKAFQTMATMSSAQLISA PSLQAKLGPTGPQASELFQFWSGGS GPPWNVPDVKPFSQTPFTLSLTPPS TDLPGYEPPQALSPLPPPTPSPPAW QARGLGTARLQLVEFSAFVEPPDAV DSYQRHLFVHISQHCPSPGAPPLES VDVRQIYDKFPEKKGGLRELYDRGP PHAFFLVKFWADLNWGPSGEEAGAG GSISSGGFYGVSSQYESLEHMTLTC SSKVCSFGKQVVEKVETERAQLEDG RFVYRLLRSPMCEYLVNFLHKLRQL PERYMMNSVLENFTILQVVTNRDTQ ELLLCTAYVFEVSTSERGAQHHIYR LVRD
• Purity: Greater than 80% as determined by SDS-PAGE.
• Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week.
• Storage: Store at -20 centigrade/-80 centigrade.

Gene Information

• Gene Name: TEAD2 TEA domain family member 2 [ Homo sapiens ]
• Official Symbol: TEAD2
• Synonyms: TEAD2; TEA domain family member 2; transcriptional enhancer factor TEF-4; ETF; TEF 4; TEF4; TEF-4; TEAD-2
• Gene ID: 8463
• mRNA Refseq: NM_001256658
• Protein Refseq: NP_001243587
• MIM: 601729
• UniProt ID: Q15562
• Chromosome Location: 19q13.3
• Pathway: Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystem; Gene Expression, organism-specific biosystem; Generic Transcription Pathway, organism-specific biosystem; Metabolism, organism-specific biosystem; Metabolism of lipids and lipoproteins, organism-specific biosystem; PPARA Activates Gene Expression, organism-specific biosystem; Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha), organism-specific biosystem
• Function: DNA binding; protein binding; sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding transcription factor activity; sequence-specific distal enhancer binding RNA polymerase II transcription factor activity