| Description : |
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGF-beta family members. Disruption of the TGF-beta/SMAD pathway has been implicated in a variety of human cancers. A chromosomal translocation that includes this gene is associated with Peters' anomaly, a congenital defect of the anterior chamber of the eye. Mutations in this gene may be associated with Loeys-Dietz syndrome. This gene encodes multiple isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Aug 2016]. |
| Source : |
CHO cell |
| Species : |
Human |
| Bio-activity : |
The ED50 is 1 - 4 ng/ml, corresponding to a specific activity of 0.25 - 1.0 x 10^6 units/mg. |
| Molecular Mass : |
12.7 kDa |
| Endotoxin : |
Less than 0.01 ng per µg protein as determined by the LAL method. |
| Purity : |
> 98% as determined by Coomassie stained SDS-PAGE. |
| Concentration : |
Protein formulated and vialed at >50 µg/mL in specified buffer |
| Storage Buffer : |
20% Acetonitrile, 0.1% TFA (Trifluoroacetic acid) |
