Recombinant Human TLR8 protein, His-tagged

• Cat.No.: TLR8-930H
• Product Overview: Recombinant Human TLR8(aa 27-827) fused with His-tag was expressed in Yeast.

Specification

• Description: The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung and peripheral blood leukocytes, and lies in close proximity to another family member, TLR7, on chromosome X.
• Source: Yeast
• Species: Human
• Tag: His
• Form: 20 mM Tris, pH 8.0, 500 mM NaCl, 50% glycerol
• Molecular Mass: 93.4 kD
• AA Sequence: EENFSRSYPC DEKKQNDSVI AECSNRRLQE VPQTVGKYVTELDLSDNFIT HITNESFQGL QNLTKINLNH NPNVQHQNGNPGIQSNGLNI TDGAFLNLKN LRELLLEDNQ LPQIPSGLPESLTELSLIQN NIYNITKEGI SRLINLKNLY LAWNCYFNKVCEKTNIEDGV FETLTNLELL SLSFNSLSHV PPKLPSSLRKLFLSNTQIKY ISEEDFKGLI NLTLLDLSGN CPRCFNAPFPCVPCDGGASI NIDRFAFQNL TQLRYLNLSS TSLRKINAAWFKNMPHLKVL DLEFNYLVGE IASGAFLTML PRLEILDLSFNYIKGSYPQH INISRNFSKL LSLRALHLRG YVFQELREDDFQPLMQLPNL STINLGINFI KQIDFKLFQN FSNLEIIYLSENRISPLVKD TRQSYANSSS FQRHIRKRRS TDFEFDPHSNFYHFTRPLIK PQCAAYGKAL DLSLNSIFFI GPNQFENLPDIACLNLSANS NAQVLSGTEF SAIPHVKYLD LTNNRLDFDNASALTELSDL EVLDLSYNSH YFRIAGVTHH LEFIQNFTNLKVLNLSHNNI YTLTDKYNLE SKSLVELVFS GNRLDILWNDDDNRYISIFK GLKNLTRLDL SLNRLKHIPN EAFLNLPASLTELHINDNML KFFNWTLLQQ FPRLELLDLR GNKLLFLTDSLSDFTSSLRT LLLSHNRISH LPSGFLSEVS SLKHLDLSSNLLKTINKSAL ETKTTTKLSM LELHGNPFEC TCDIGDFRRWMDEHLNVKIP RLVDVICASP GDQRGKSIVS LELTTCVSDVT
• Storage: Long term: -80 centigrade; Short term: -20 centigrade. Avoid freeze-thaw cycles.

Gene Information

• Gene Name: TLR8 toll-like receptor 8 [ Homo sapiens ]
• Official Symbol: TLR8
• Synonyms: TLR8; toll-like receptor 8; CD288; MGC119599; MGC119600
• Gene ID: 51311
• mRNA Refseq: NM_138636
• Protein Refseq: NP_619542
• MIM: 300366
• UniProt ID: Q9NR97
• Chromosome Location: Xp22
• Pathway: Immune System, organism-specific biosystem; Innate Immune System, organism-specific biosystem; MyD88 dependent cascade initiated on endosome, organism-specific biosystem; TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling, organism-specific biosystem; TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, organism-specific biosystem; Toll Like Receptor 7/8 (TLR7/8) Cascade, organism-specific biosystem; Toll Like Receptor 9 (TLR9) Cascade, organism-specific biosystem
• Function: DNA binding; RNA binding; double-stranded RNA binding; receptor activity; single-stranded RNA binding