Active Recombinant Human TNF protein
Cat.No. : | TNF-246H |
Product Overview : | Recombinant Human TNF(Val77-Leu233) was expressed in E. coli. |
- Specification
- Gene Information
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Description : | This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine. |
Source : | E. coli |
Species : | Human |
Form : | 10mM NaH2PO4, 150mM NaCl, pH7.2 |
Bio-activity : | The ED50 is 0.020-0.050 ng/ml, corresponding to a specific activity of 5-2 X10^7 units/mg, determined by a dose dependent stimulation of L929 cells treated with actinomycin D. |
Molecular Mass : | 17 kDa |
Protein length : | Val77-Leu233 |
Endotoxin : | Less than 0.01 ng per ug protein as determined by the LAL method. |
Purity : | Purity is >98%, as determined by Coomassie stained SDS-PAGE. |
Concentration : | Protein formulated and vialed at >50 ug/mL in specified buffer |
Gene Name : | TNF tumor necrosis factor [ Homo sapiens ] |
Official Symbol : | TNF |
Synonyms : | TNF; tumor necrosis factor; TNFA, tumor necrosis factor (TNF superfamily, member 2); DIF; TNF superfamily; member 2; TNF alpha; TNFSF2; TNF-a; cachectin; APC1 protein; TNF, monocyte-derived; TNF, macrophage-derived; TNF superfamily, member 2; tumor necrosis factor alpha; tumor necrosis factor-alpha; tumor necrosis factor ligand superfamily member 2; TNFA; TNF-alpha; |
Gene ID : | 7124 |
mRNA Refseq : | NM_000594 |
Protein Refseq : | NP_000585 |
MIM : | 191160 |
UniProt ID : | P01375 |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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