Recombinant Human TNFAIP3 protein, MYC/DDK-tagged

• Cat.No.: TNFAIP3-159H
• Product Overview: Recombinant Human TNFAIP3 fused with MYC/DDK tag at C-terminal was expressed in HEK293.

Specification

• Description: This gene was identified as a gene whose expression is rapidly induced by the tumor necrosis factor (TNF). The protein encoded by this gene is a zinc finger protein and ubiqitin-editing enzyme, and has been shown to inhibit NF-kappa B activation as well as TNF-mediated apoptosis. The encoded protein, which has both ubiquitin ligase and deubiquitinase activities, is involved in the cytokine-mediated immune and inflammatory responses. Several transcript variants encoding the same protein have been found for this gene.
• Source: HEK293
• Species: Human
• Tag: MYC/DDK
• Form: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 89.4 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Notes: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Concentration: >50 ug/mL as determined by microplate BCA metho

Gene Information

• Gene Name: TNFAIP3 tumor necrosis factor, alpha-induced protein 3 [ Homo sapiens ]
• Official Symbol: TNFAIP3
• Synonyms: TNFAIP3; tumor necrosis factor, alpha-induced protein 3; tumor necrosis factor alpha-induced protein 3; A20; OTUD7C; TNFAIP3 (A20); zinc finger protein A20; TNF alpha-induced protein 3; OTU domain-containing protein 7C; putative DNA-binding protein A20; tumor necrosis factor inducible protein A20; TNFA1P2; MGC104522; MGC138687; MGC138688
• Gene ID: 7128
• mRNA Refseq: NM_006290
• Protein Refseq: NP_006281
• MIM: 191163
• UniProt ID: P21580
• Chromosome Location: 6q23-q25
• Pathway: CD40/CD40L signaling, organism-specific biosystem; Canonical NF-kappaB pathway, organism-specific biosystem; Immune System, organism-specific biosystem; Innate Immune System, organism-specific biosystem; Measles, organism-specific biosystem; Measles, conserved biosystem; NOD-like receptor signaling pathway, organism-specific biosystem
• Function: DNA binding; cysteine-type endopeptidase inhibitor activity involved in apoptotic process; cysteine-type peptidase activity; kinase binding; ligase activity; metal ion binding; peptidase activity; protease binding; protein binding; protein self-association; ubiquitin binding; ubiquitin thiolesterase activity; ubiquitin-protein ligase activity; ubiquitin-specific protease activity; ubiquitin-specific protease activity; zinc ion binding