Active Recombinant Human TNFRSF10A Protein

• Cat.No.: TNFRSF10A-312H
• Product Overview: Recombinant Human TNFRSF10A was expressed in E. coli.

Specification

• Description: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell death signal and induces cell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein.
• Source: E. coli
• Species: Human
• Form: Lyophilized from a 0.2 µM filtered solution of 20mM phosphate buffer, 100mM NaCl, pH 7.2
• Bio-activity: Measured by its ability to inhibit apoptosis in LN-18 cells. The expected ED50 for this effect is 0.4 -0.5 ug/ml.
• Molecular Mass: 22.7 kDa
• AA Sequence: MSGTGAAAATPSKVWGSSAGRIEPR GGGRGALPTSMGQHGPSARARAGRA PGPRPAREASPRLRVHKTFKFVVVG VLLQVVPSSAATIKLHDQSIGTQQW EHSPLGELCPPGSHRSERPGACNRC TEGVGYTNASQQLFACLPCTACKSD EEERSPCTTTRNTACQCKPGTFRND NSAEMCRKCSTGCPRGMVKVKDCTP WSDIECVHKESGNGHN
• Endotoxin: Endotoxin level is <0.1 ng/µg of protein (<1EU/µg).
• Purity: >95% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: Resuspend the protein in the desired concentration in proper buffer

Gene Information

• Gene Name: TNFRSF10A tumor necrosis factor receptor superfamily, member 10a [ Homo sapiens ]
• Official Symbol: TNFRSF10A
• Synonyms: TNFRSF10A; tumor necrosis factor receptor superfamily, member 10a; tumor necrosis factor receptor superfamily member 10A; Apo2; CD261; DR4; TRAILR 1; TRAIL-R1; TRAIL receptor 1; death receptor 4; cytotoxic TRAIL receptor; TNF-related apoptosis-inducing ligand receptor 1; tumor necrosis factor receptor superfamily member 10a variant 2; APO2; TRAILR1; TRAILR-1; MGC9365
• Gene ID: 8797
• mRNA Refseq: NM_003844
• Protein Refseq: NP_003835
• MIM: 603611
• UniProt ID: O00220