Active Recombinant Human TNFRSF17 protein, Fc-tagged

• Cat.No.: TNFRSF17-1817H
• Product Overview: Human BCMA, Fc Tag is expressed from human 293 cells (HEK293). It contains AA Met 1 - Ala 54 (Accession # NP_001183.2).

Specification

• Description: Tumor necrosis factor receptor superfamily member 17 (TNFRSF17) is also known as B-cell maturation protein (BCMA), CD antigen CD269, which is a member of the TNF-receptor superfamily. TNFRSF17 contains one TNFR-Cys repeat. TNFRSF17 is expressed in mature B-cells, but not in T-cells or monocytes. TNFRSF17 is receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. TNFRSF17 promotes B-cell survival and plays a role in the regulation of humoral immunity. TNFRSF17 can activate NF-kappa-B and JNK.
• Source: HEK293
• Species: Human
• Tag: Fc
• Predicted N Terminal: Met 1
• Form: Lyophilized from 0.22 μm filtered solution in 50 mM tris, 100 mM glycine, pH7.5, 10% trehalose.
• Bio-activity: Immobilized Human BCMA, Fc Tag at 10μg/mL (100 μL/well) can bind FITC-Labeled Human BAFF, Fc Tag with a linear range of 0.31-1.25 μg/mL.
• Molecular Mass: This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 32 kDa. As a result of glycosylation, The protein migrates as 35-40 kDa under reducing (R) condition and 66 kDa under non-reducing (NR) condition on SDS-PAGE gel.
• Protein length: AA Met 1 - Ala 54
• Endotoxin: Less than 1.0 EU per μg by the LAL method.
• Purity: >95% as determined by SDS-PAGE.
• Storage: For long term storage, the product should be stored at lyophilized state at -20°C or lower. Please avoid repeated freeze-thaw cycles. No activity loss is observed after storage at: 4-8°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution.
• Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents.

Gene Information

• Gene Name: TNFRSF17 TNF receptor superfamily member 17 [ Homo sapiens (human) ]
• Official Symbol: TNFRSF17
• Synonyms: BCM; BCMA; CD269; TNFRSF13A; B cell maturation antigen; B-cell maturation factor; B-cell maturation protein
• Gene ID: 608
• mRNA Refseq: NM_001192.2
• Protein Refseq: NP_001183.2
• UniProt ID: Q02223