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Recombinant Human TNFRSF9 protein, His-tagged

Cat.No. : TNFRSF9-576H
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  • Gene Information
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Product overview : Recombinant Human TNFRSF9 (Q07011) aa. (Asn40~Glu153) fused with His tag was produced in E. coli cells.
Description : The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contributes to the clonal expansion, survival, and development of T cells. It can also induce proliferation in peripheral monocytes, enhance T cell apoptosis induced by TCR/CD3 triggered activation, and regulate CD28 co-stimulation to promote Th1 cell responses. The expression of this receptor is induced by lymphocyte activation. TRAF adaptor proteins have been shown to bind to this receptor and transduce the signals leading to activation of NF-kappaB.
Source : E. coli
Species : Human
Tag : His
Form : Freeze-dried powder
Molecular Mass : Predicted Molecular Mass: 13.6kDa; Accurate Molecular Mass: 16kDa as determined by SDS-PAGE reducing conditions.
Protein length : Asn40~Glu153
Purity : >98%
Characteristic : Isoelectric point is 8.3.
Applications : Cell culture; Activity Assays; In vivo assays.
Stability : The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Storage : Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
Storage buffer : 20mM Tris, 150mM NaCl,pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% sarcosyl, 5% Trehalose and Proclin300.
Reconstitution : Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex
Gene Name : TNFRSF9 TNF receptor superfamily member 9 [ Homo sapiens (human) ]
Official Symbol : TNFRSF9
Synonyms : TNFRSF9; TNF receptor superfamily member 9; ILA; 4-1BB; CD137; CDw137; tumor necrosis factor receptor superfamily member 9; 4-1BB ligand receptor; CD137 antigen; T cell antigen ILA; T-cell antigen 4-1BB homolog; homolog of mouse 4-1BB; induced by lymphocyte activation (ILA); interleukin-activated receptor, homolog of mouse Ly63; receptor protein 4-1BB
Gene ID : 3604
mRNA Refseq : NM_001561.5
Protein Refseq : NP_001552.2
UniProt ID : Q07011

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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What diseases are associated with abnormal expression levels of TNFRSF9? 12/10/2022

Studies have found that abnormal expression levels of TNFRSF9 may be associated with certain tumors, autoimmune diseases, and inflammatory diseases.

What is the association of TNFRSF9 with other cytokines? 10/27/2022

It has a variety of associations with other proteins and cytokines. For example, it may interact with the NF-kB signaling pathway to regulate the inflammatory response, and it may also interact with apoptosis-related proteins to regulate the apoptosis process.

What are the main functions of TNFRSF9 in the human body? 07/11/2022

TNFRSF9 mainly plays an important role in the immune system, as an activating signaling molecule, it is able to stimulate the activation, proliferation and survival of T cells and NK cells.

Are there potential therapeutic applications for TNFRSF9 inhibitors or activators? 08/21/2021

Inhibitors or activators targeting TNFRSF9 may have potential applications for the treatment of certain tumors, autoimmune diseases, and inflammatory diseases.

How does TNFRSF9 bind to its ligands? 06/08/2021

The extracellular domain of TNFRSF9 can bind to its ligand, such as 4-1BBL, to initiate signal transduction, which in turn activates downstream signaling pathways.

How is TNFRSF9 related to immuno-oncology? 05/27/2020

TNFRSF9 has some potential in tumor immunotherapy. Several antibody drugs have been developed to use the stimulating effects of TNFRSF9 to enhance the activity of immune cells to fight tumors.

Customer Reviews (3)

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Reviews
03/11/2022

    Good heat resistance, long time treatment at high temperature, still has activity.

    10/11/2021

      The results obtained by SDS-PAGE or Western blot analysis were good.

      07/30/2021

        The purity is good, and the experimental results obtained are accurate.

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