Recombinant Human TNNI3 protein, His-tagged
Cat.No. : | TNNI3-18H |
Product Overview : | Recombinant Human TNNI3 fused with His tag at N-terminal was expressed in E. coli. |
- Specification
- Gene Information
- Related Products
Description : | Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM). |
Source : | E. coli |
Species : | Human |
Tag : | His |
Form : | Supplied as lyophilized form in PBS, pH7.4, containing 1mM DTT, 5% trehalose, 0.05% sarcosyl and preservative. |
Molecular Mass : | 24.6kDa |
AA Sequence : | MGHHHHHHSGSEFMADGSSDAAR EPRPAPAPIR RRSSNYRAYA TEPHAKKKSK ISASRKLQLK TLLLQIAKQE LEREAEERRG EKGRALSTRC QPLELAGLGF AELQDLCRQL HARVDKVDEE RYDIEAKVTK NITEIADLTQ KIFDLRGKFK RPTLRRVRIS ADAMMQALLG ARAKESLDLR AHLKQVKKED TEKENREVGD WRKNIDALSG MEG |
Endotoxin : | <1.0EU per 1µg (determined by the LAL method) |
Applications : | SDS-PAGE; WB; ELISA; IP. |
Storage : | Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months. |
Reconstitution : | Reconstitute in sterile PBS, pH7.2 - pH7.4. |
Gene Name : | TNNI3 troponin I type 3 (cardiac) [ Homo sapiens ] |
Official Symbol : | TNNI3 |
Synonyms : | TNNI3; troponin I type 3 (cardiac); troponin I, cardiac; troponin I, cardiac muscle; CMH7; TNNC1; RCM1; cTnI; CMD2A; CMD1FF; MGC116817; |
Gene ID : | 7137 |
mRNA Refseq : | NM_000363 |
Protein Refseq : | NP_000354 |
MIM : | 191044 |
UniProt ID : | P19429 |
Chromosome Location : | 19q13.4 |
Pathway : | Cardiac muscle contraction, organism-specific biosystem; Cardiac muscle contraction, conserved biosystem; Dilated cardiomyopathy, organism-specific biosystem; Dilated cardiomyopathy, conserved biosystem; Hypertrophic cardiomyopathy (HCM), organism-specific biosystem; Hypertrophic cardiomyopathy (HCM), conserved biosystem; Muscle contraction, organism-specific biosystem; |
Function : | actin binding; calcium channel inhibitor activity; calcium-dependent protein binding; protein binding; protein domain specific binding; protein kinase binding; troponin C binding; troponin T binding; |
Products Types
◆ Recombinant Protein | ||
TNNI3-2683H | Recombinant Human TNNI3 protein(11-130 aa), N-SUMO & N-His-tagged | +Inquiry |
TNNI3-2227H | Recombinant Human TNNI3 Protein, His (Fc)-Avi-tagged | +Inquiry |
TNNI3-2254H | Recombinant Human TNNI3 Protein, MYC/DDK-tagged | +Inquiry |
Tnni3-6569M | Recombinant Mouse Tnni3 Protein, Myc/DDK-tagged | +Inquiry |
TNNI3-5866R | Recombinant Rat TNNI3 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Native Protein | ||
TNNI3-221H | Native Human TNNI3 | +Inquiry |
TNNI3-01H | Native Human TNNI3 Protein | +Inquiry |
TNNI3-223H | Native Human Troponin I Type 3 (Cardiac) | +Inquiry |
◆ Lysates | ||
TNNI3-1803HCL | Recombinant Human TNNI3 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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