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Recombinant Human TPBG Protein, His-tagged

Cat.No. : TPBG-656H
Product Overview : Recombinant Human TPBG(Ser32~Ser351) fused with His tag at N-terminal was expressed in E. coli.
  • Specification
  • Gene Information
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Description : This gene encodes a leucine-rich transmembrane glycoprotein that may be involved in cell adhesion. The encoded protein is an oncofetal antigen that is specific to trophoblast cells. In adults this protein is highly expressed in many tumor cells and is associated with poor clinical outcome in numerous cancers. Alternate splicing in the 5' UTR results in multiple transcript variants that encode the same protein.
Source : E. coli
Species : Human
Tag : His
Form : 20mM Tris, 150mM NaCl,pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300.
Molecular Mass : 38.7kDa
Identity : Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex.
Protein length : Ser32~Ser351
Endotoxin : <1.0EU per 1µg (determined by the LAL method)
Purity : > 97%
Applications : Positive Control; Immunogen; SDS-PAGE; WB.
If bio-activity of the protein is needed, please check active protein
Stability : The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Storage : Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
Reconstitution : Reconstitute in PBS or others
Gene Name : TPBG trophoblast glycoprotein [ Homo sapiens ]
Official Symbol : TPBG
Synonyms : TPBG; trophoblast glycoprotein; 5T4; 5T4 AG; 5T4 oncofetal antigen; 5T4 oncotrophoblast glycoprotein; 5T4 oncofetal trophoblast glycoprotein; M6P1; 5T4AG;
Gene ID : 7162
mRNA Refseq : NM_001166392
Protein Refseq : NP_001159864
MIM : 190920
UniProt ID : Q13641

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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What is the significance of TPBG in cancer diagnosis or prognosis? 01/23/2022

Elevated TPBG levels can serve as a biomarker and may correlate with poor prognosis in some cancers.

Are there any known post-translational modifications of TPBG, and what are their effects? 07/08/2021

While the post-translational modifications of TPBG are not fully elucidated, they could affect its localization, stability, and interactions with other proteins.

What known proteins interact with TPBG, influencing its function? 03/15/2021

Specific interacting partners of TPBG that significantly influence its function are still under investigation.

How does TPBG expression change in cancerous cells? 03/01/2021

TPBG expression is often upregulated in various types of cancer cells.

How does TPBG contribute to the immune evasion of cancer cells? 06/27/2020

TPBG might contribute to immune evasion by interacting with immune cells and modulating immune responses.

What is the primary biological role of TPBG in normal cells? 02/09/2020

TPBG plays roles in cell adhesion, migration, and proliferation in normal cells.

What potential therapeutic interventions could target TPBG? 07/14/2019

Targeting TPBG could provide a therapeutic avenue, particularly in cancers where it is overexpressed, potentially improving immune response and treatment outcomes.

Customer Reviews (3)

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Reviews
09/01/2022

    Reliable and reproducible results.

    04/28/2021

      Worked well for Western blot.

      06/17/2018

        Great for research purposes.

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