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Active Recombinant Human TPP1 protein, His-tagged

Cat.No. : TPP1-926H
Product Overview : Recombinant Human TPP1 protein(AAH14863.1)(Met1-Pro563), fused with His tag, was expressed in Insect Cells.
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Source : Insect Cells
Species : Human
Tag : His
Form : Supplied as sterile 20mM Tris, 500mM NaCl, pH 7.4, 10% glyPlease contact us for any concerns or special requirements.Please refer to the specific buffer information in the hard copy of CoA.
Bio-activity : Measured by the cleavage of AlaAlaPheAMC. The specific activity is > 850 pmoles/min/μg.
Molecular Mass : The secreted recombinant human TPP1 (pro form) comprises 554 amino acids and has a predicted molecular mass of 60.7 kDa. The apparent molecular mass of rhTPP1 is approximately 60 kDa in SDS-PAGE under reducing conditions.
Protein Length : Met1-Pro563
Endotoxin : < 1.0 EU per μg of the protein as determined by the LAL method
Purity : > 95 % as determined by SDS-PAGE
Storage : Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4°C before opening to recover the entire contents.
Gene Name : TPP1 tripeptidyl peptidase I [ Homo sapiens ]
Official Symbol : TPP1
Synonyms : TPP1; tripeptidyl peptidase I; ceroid lipofuscinosis, neuronal 2, late infantile (Jansky Bielschowsky disease) , CLN2; tripeptidyl-peptidase 1; TPP I; tripeptidyl aminopeptidase; growth-inhibiting protein 1; cell growth-inhibiting gene 1 protein; lysosomal pepstatin insensitive protease; CLN2; GIG1; LPIC; TPP-1; MGC21297;
Gene ID : 1200
mRNA Refseq : NM_000391
Protein Refseq : NP_000382
MIM : 607998
UniProt ID : O14773

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Are there any specific inhibitors developed to target PKMYT1? 01/01/2023

Yes, several PKMYT1 inhibitors are under development and in preclinical and clinical trials for evaluating their efficacy in cancer treatment.

Are there ongoing clinical trials targeting PKMYT1? 09/03/2020

Yes, several clinical trials are investigating the efficacy of PKMYT1 inhibitors in various cancer types.

How does PKMYT1 influence cell cycle progression? 02/22/2019

PKMYT1 regulates the cell cycle by inhibiting the activity of cyclin-dependent kinases (CDKs), particularly CDK1, which is crucial for G2/M phase transition.

Can PKMYT1 be used as a predictive biomarker in cancer patients? 10/22/2017

Yes, the expression levels of PKMYT1 can be indicative of the responsiveness of cancer cells to specific treatments, making it a potential predictive biomarker.

How does PKMYT1 inhibition affect normal cell function? 07/30/2016

Selective PKMYT1 inhibitors aim to minimize effects on normal cells, but potential impacts on the cell cycle of non-cancerous cells are still under investigation.

Customer Reviews (3)

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Reviews
06/23/2019

    These resources can enhance the efficiency and accuracy of experimental workflows and contribute to successful outcomes.

    12/07/2018

      The manufacturer's support is crucial for researchers using TPP1 protein in trials.

      09/16/2018

        Their collaboration, expertise, and customized solutions contribute to the successful execution of experiments, reliable data generation, and the advancement of scientific knowledge in the field.

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