| Description : |
This gene is a member of the Ig superfamily and encodes a cell surface sialoglycoprotein expressed by cytokine-activated endothelium. This type I membrane protein mediates leukocyte-endothelial cell adhesion and signal transduction, and may play a role in the development of artherosclerosis and rheumatoid arthritis. Three alternatively spliced transcripts encoding different isoforms have been described for this gene. |
| Source : |
HEK293 |
| Species : |
Human |
| Form : |
Lyophilized from a 0.2 µM filtered solution of 20mM phosphate buffer, 100mM NaCl, pH 7.2 |
| Bio-activity : |
Determined by its ability to support the adhesion of human U937 cells. The expected ED50 for this effect is 0.8-1.0ug/mL. |
| Molecular Mass : |
74 kDa |
| AA Sequence : |
FKIETTPESRYLAQIGDSVSLTCST TGCESPFFSWRTQIDSPLNGKVTNE GTTSTLTMNPVSFGNEHSYLCTATC ESRKLEKGIQVEIYSFPKDPEIHLS GPLEAGKPITVKCSVADVYPFDRLE IDLLKGDHLMKSQEFLEDADRKSLE TKSLEVTFTPVIEDIGKVLVCRAKL HIDEMDSVPTVRQAVKELQVYISPK NTVISVNPSTKLQEGGSVTMTCSSE GLPAPEIFWSKKLDNGNLQHLSGNA TLTLIAMRMEDSGIYVCEGVNLIGK NRKEVELIVQEKPFTVEISPGPRIA AQIGDSVMLTCSVMGCESPSFSWRT QIDSPLSGKVRSEGTNSTLTLSPVS FENEHSYLCTVTCGHKKLEKGIQVE LYSFPRDPEIEMSGGLVNGSSVTVS CKVPSVYPLDRLEIELLKGETILEN IEFLEDTDMKSLENKSLEMTFIPTI EDTGKALVCQAKLHIDDMEFEPKQR QSTQTLYVNVAPRDTTVLVSPSSIL EEGSSVNMTCLSQGFPAPKILWSRQ LPNGELQPLSENATLTLISTKMEDS GVYLCEGINQAGRSRKEVELIIQVT PKDIKLTAFPSESVKEGDTVIISCT CGNVPETWIILKKKAETGDTVLKSI DGAYTIRKAQLKDAGVYECESKNKV GSQLRSLTLDVQGRENNKDYFSP |
| Endotoxin : |
Endotoxin level is <0.1 ng/µg of protein (<1EU/µg). |
| Purity : |
>95% as determined by SDS-PAGE and Coomassie blue staining |
| Concentration : |
Resuspend the protein in the desired concentration in proper buffer |
