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Recombinant Human VCL protein

Cat.No. : VCL-230H
Product Overview : Recombinant Human VCL, transcript variant 2, was expressed in E. coli.
  • Specification
  • Gene Information
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Description : Vinculin is a cytoskeletal protein associated with cell-cell and cell-matrix junctions, where it is thought to function as one of several interacting proteins involved in anchoring F-actin to the membrane. Defects in VCL are the cause of cardiomyopathy dilated type 1W. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined.
Source : E. coli
Species : Human
Form : Lyophilized from a 0.2 µM filtered solution of 20mM PB, 150mM NaCl, pH 7.2
Molecular Mass : 117kD
AA Sequence : MPVFHTRTIESILEPVAQQISHLVI MHEEGEVDGKAIPDLTAPVAAVQAA VSNLVRVGKETVQTTEDQILKRDMP PAFIKVENACTKLVQAAQMLQSDPY SVPARDYLIDGSRGILSGTSDLLLT FDEAEVRKIIRVCKGILEYLTVAEV VETMEDLVTYTKNLGPGMTKMAKMI DERQQELTHQEHRVMLVNSMNTVKE LLPVLISAMKIFVTTKNSKNQGIEE ALKNRNFTLEKMSAEINEIIRVLQL TSWDE
Endotoxin : Endotoxin level is <0.1 ng/µg of protein (<1EU/µg).
Purity : >95% as determined by SDS-PAGE and Coomassie blue staining
Concentration : Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 µg/ml. Dissolve the lyophilized protein in 1X PBS. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
Gene Name : VCL vinculin [ Homo sapiens ]
Official Symbol : VCL
Synonyms : VCL; vinculin; metavinculin; MVCL; CMD1W; CMH15;
Gene ID : 7414
mRNA Refseq : NM_003373
Protein Refseq : NP_003364
MIM : 193065
UniProt ID : P18206

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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