Recombinant Human WHSC1 protein, FLAG/His-tagged

• Cat.No.: WHSC1-185H
• Product Overview: Recombinant Human WHSC1(782-end) fused with FLAG/His tag at N-terminal was expressed in Insect cells.

Specification

• Description: NSD2 is a histone methyltransferase that preferentially methylates Lys27 of histone H3. Isoform RE-IIBP may act as a transcription regulator that binds DNA and suppresses IL5 transcription through HDAC recruitment. Mutations in the gene for NSD2 are linked to Wolf-Hirschhorn syndrome (WHS), a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4, and is also associated with chromosomal translocations in multiple myelomas.
• Source: Insect cells
• Species: Human
• Tag: FLAG/His
• Form: 45 mM Tris-HCl, pH 8.0, 124 mM NaCl, 2.4 mM, 10% glycerol, 90 µg/ml FLAG peptide and 3 mM DTT.
• Molecular Mass: 66.5 kDa
• Purity: >30%
• Applications: Suitable for protein binding studies, as an immunogen, or as a Western blotting control.
• Storage: >6 months at -80 centigrade. Avoid freeze/thaw cycles.
• Concentration: 0.09 mg/ml

Gene Information

• Gene Name: WHSC1 Wolf-Hirschhorn syndrome candidate 1 [ Homo sapiens ]
• Official Symbol: WHSC1
• Synonyms: WHSC1; Wolf-Hirschhorn syndrome candidate 1; probable histone-lysine N-methyltransferase NSD2; MMSET; NSD2; trithorax/ash1-related protein 5; nuclear SET domain-containing protein 2; IL5 promoter REII region-binding protein; multiple myeloma SET domain containing protein type III; WHS; TRX5; REIIBP; FLJ23286; KIAA1090; MGC176638
• Gene ID: 7468
• mRNA Refseq: NM_133330
• Protein Refseq: NP_579877
• MIM: 602952
• UniProt ID: O96028
• Chromosome Location: 4p16.3
• Pathway: Lysine degradation, organism-specific biosystem; Lysine degradation, conserved biosystem; Transcriptional misregulation in cancer, organism-specific biosystem; Transcriptional misregulation in cancer, conserved biosystem
• Function: DNA binding; histone-lysine N-methyltransferase activity; metal ion binding; methyltransferase activity; transferase activity; zinc ion binding