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Recombinant Human WNT3A protein

Cat.No. : WNT3A-457H
Product Overview : Recombinant Human WNT3A(19-352aa) was expressed in E. coli.
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  • Gene Information
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Description : The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. WNT3a is a member of the WNT gene family. It encodes a protein which shows 96% amino acid identity to mouse Wnt3A protein, and 84% to human WNT3 protein, another WNT gene product. This protein is clustered with WNT14 gene, another family member, in chromosome 1q42 region.
Source : E. coli
Species : Human
Form : Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 10% glycerol
Molecular Mass : 37.5 kDa (335aa)
AA Sequence : MSYPIWWSLA VGPQYSSLGS QPILCASIPG LVPKQLRFCR NYVEIMPSVA EGIKIGIQEC QHQFRGRRWN CTTVHDSLAI FGPVLDKATRESAFVHAIAS AGVAFAVTRS CAEGTAAICG CSSRHQGSPG KGWKWGGCSE DIEFGGMVSR EFADARENRP DARSAMNRHN NEAGRQAIASHMHLKCKCHG LSGSCEVKTC WWSQPDFRAI GDFLKDKYDS ASEMVVEKHR ESRGWVETLR PRYTYFKVPT ERDLVYYEAS PNFCEPNPETGSFGTRDRTC NVSSHGIDGC DLLCCGRGHN ARAERRREKC RCVFHWCCYV SCQECTRVYD VHTCK
Purity : > 85% by SDS - PAGE
Storage : Can be stored at +4 centigrade short term (1-2 weeks). For long term storage, aliquot and store at -20 centigrade or -70 centigrade. Avoid repeated freezing and thawing cycles.
Concentration : 0.5mg/ml (determined by Bradford assay)
Gene Name : WNT3A wingless-type MMTV integration site family, member 3A [ Homo sapiens ]
Official Symbol : WNT3A
Synonyms : WNT3A; wingless-type MMTV integration site family, member 3A; protein Wnt-3a; MGC119418; MGC119419; MGC119420;
Gene ID : 89780
mRNA Refseq : NM_033131
Protein Refseq : NP_149122
MIM : 606359
UniProt ID : P56704
Chromosome Location : 1q42
Pathway : Basal cell carcinoma, organism-specific biosystem; Basal cell carcinoma, conserved biosystem; Canonical Wnt signaling pathway, organism-specific biosystem; Class B/2 (Secretin family receptors), organism-specific biosystem; DNA damage response (only ATM dependent), organism-specific biosystem; GPCR ligand binding, organism-specific biosystem; HTLV-I infection, organism-specific biosystem;
Function : extracellular matrix structural constituent; frizzled-2 binding; protein binding; protein domain specific binding; receptor agonist activity; transcription coactivator activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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Does CDH16 protein interact with WNT3A protein? 12/14/2019

No interaction between CDH16 protein and WNT3A protein has been found.

Which role of WNT3A protein in embryonic development? 09/15/2019

The WNT3A protein plays an important role in embryonic development. It is involved in the formation of multiple embryonic organs, directed cell migration, and the establishment of tissue polarity.

Have regulators of WNT3A protein been identified? 08/24/2019

Yes, multiple factors have been found in the WNT signaling pathway that regulate the expression and function of WNT3A protein, including Axin, APC, etc.

Where is the WNT3A protein in the Wnt signaling pathway? 05/18/2019

The WNT3A protein is in the starting position in the Wnt signaling pathway, and it is able to bind to the Wnt receptor and initiate the signaling cascade.

What is the relationship between WNT3A protein and cancer stem cells? 05/04/2019

WNT3A protein is closely related to cancer stem cells. It may be involved in the self-renewal and differentiation regulation of cancer stem cells, which is of great significance for tumor development and treatment.

How about the current clinical research progress on WNT3A protein? 03/28/2019

Clinical research on WNT3A protein is still ongoing. Studies have shown the important role of WNT3A protein in tumors, neurological diseases, bone metabolism diseases, etc., and future research will further explore its application potential in disease diagnosis, treatment and prognosis assessment.

Customer Reviews (3)

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Reviews
07/15/2022

    This protein is highly expressed and can efficiently synthesize a large number of target proteins in host cells.

    06/03/2022

      This protein has therapeutic effects on specific disease models and is a promising candidate for new drugs.

      11/20/2019

        The laboratory personnel feedback that the protein is easy to operate, can meet the experimental needs, and has a good cost performance.

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