|Product Overview:||Recombinant M. tamulus Iberiotoxin was expressed in E. coli.|
|Description:||The single chain peptide iberiotoxin (IbTX) is a selective and reversible inhibitor of high-conductance calcium-activated potassium channels. It occurs naturally in the venom of the scorpion Buthus tamulus. IbTX also modulates the binding of charybdotoxin (CbTX) to smooth muscle sarcolemmal membranes in a non-competitive manner. IbTX is similar in size to CbTX and shares considerable sequence homology with CbTX. However, IbTX differs in its overall charge in having one fewer basic and four more acidic residues than CbTX.|
|Unit Definition:||10-20 units/mg protein (using 4MU-NANA), 3.5-8.0 units/mg protein (mucin)|
|Stability:||Stock solutions of 1 μM can be aliquoted and stored at -20 centigrade for up to 3 months.|
|Storage:||Store at -20 centigrade|
|Reconstitution:||Soluble in aqueous buffers.|
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