Recombinant Mouse Adam17 protein, His-tagged
Cat.No. : | Adam17-256M |
Product Overview : | Recombinant Mouse Adam17 protein (Pro18-Asp563), fused to His tag at C-terminus, was expressed in human 293 cells (HEK293). |
- Specification
- Gene Information
- Related Products
Description : | Disintegrin and metalloproteinase domain-containing protein 17 (ADAM17), a member of the ADAM protein family of disintegrins and metalloproteases, is also known as TNF-alpha convertase, TNF-alpha-converting enzyme and CD156b, which contains one disintegrin domain and one peptidase M12B domain. ADAM17 can cleave the membrane-bound precursor of TNF-alpha to its mature soluble form. ADAM17 is also responsible for the proteolytical release of soluble JAM3 from endothelial cells surface (By similarity) and proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Furthermore, ADAM17 acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called Notch extracellular truncation. |
Source : | HEK293 |
Species : | Mouse |
Tag : | His |
Form : | Lyophilized from 0.22 um filtered solution in 50 mM MES, 150 mM NaCl, pH6.5, 10% trehalose. |
Molecular Mass : | The protein has a calculated MW of 63.4 kDa. The protein migrates as 19 kDa and 20 kDa (Propeptide), 55-66 kDa (Mature-ADAM17) and 75-94 kDa (Pro-ADAM17) under reducing (R) condition (SDS-PAGE) due to glycosylation. |
Protein length : | 546 |
Endotoxin : | Less than 1.0 EU per ug by the LAL method. |
Purity : | >85% as determined by SDS-PAGE. |
Storage : | For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower. Please avoid repeated freeze-thaw cycles. This product is stable after storage at: -20 centigrade to -70 centigrade for 12 months in lyophilized state; -70 centigrade for 3 months under sterile conditions after reconstitution. |
Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents. |
Gene Name : | Adam17 |
Official Symbol : | Adam17 |
Synonyms : | ADAM17; a disintegrin and metallopeptidase domain 17; disintegrin and metalloproteinase domain-containing protein 17; ADAM 17; TNF-alpha convertase; TNF-alpha converting enzyme; TNF-alpha-converting enzyme; a disintegrin and metalloproteinase domain 17; a disintegrin and metalloprotease domain 17; Tace; CD156b |
Gene ID : | 11491 |
mRNA Refseq : | NM_009615 |
Protein Refseq : | NP_033745 |
UniProt ID : | Q9Z0F8 |
Products Types
◆ Recombinant Protein | ||
Adam17-308M | Recombinant Mouse Adam17 Protein, His (Fc)-Avi-tagged | +Inquiry |
ADAM17-157R | Recombinant Rat ADAM17 Protein, His (Fc)-Avi-tagged | +Inquiry |
ADAM17-073R | Recombinant Rat ADAM17 Protein, His-tagged | +Inquiry |
Adam17-8788R | Active Recombinant Rat Adam17 protein(Met1-Asp563), His-tagged | +Inquiry |
ADAM17-085M | Recombinant Mouse ADAM17 Protein, His-tagged | +Inquiry |
◆ Lysates | ||
ADAM17-1198RCL | Recombinant Rat ADAM17 cell lysate | +Inquiry |
◆ Assay kits | ||
Kit-0049 | ADAM17 Inhibitor Screening Assay Kit | +Inquiry |
Kit-0048 | ADAM17 fluorometric drug discovery Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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