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Recombinant Mouse ARNT2 Protein

Cat.No. : ARNT2-1962M
Product Overview : Recombinant Mouse ARNT2 full length or partial length protein was expressed.
  • Specification
  • Gene Information
  • Related Products
Source : Mammalian Cells
Species : Mouse
Tag : His
Form : Liquid or lyophilized powder
Endotoxin : < 1.0 EU per μg of the protein as determined by the LAL method.
Purity : >80%
Notes : This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
Storage : Store it at +4 ºC for short term. For long term storage, store it at -20 ºC~-80 ºC.
Storage Buffer : PBS buffer
Gene Name : Arnt2 aryl hydrocarbon receptor nuclear translocator 2 [ Mus musculus ]
Official Symbol : ARNT2
Gene ID : 11864
mRNA Refseq : NM_007488.2
Protein Refseq : NP_031514.2
MIM :
UniProt ID : Q61324

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (25)

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Can ARNT2 be targeted for therapeutic interventions? 10/29/2022

Targeting ARNT2 for therapeutic interventions is a potential avenue for the treatment of neurodevelopmental disorders and other neurological conditions. However, more research is needed to fully understand the mechanisms of ARNT2 function and its potential as a therapeutic target.

Are there any known drugs or compounds that target ARNT2? 07/19/2022

Currently, there are no specific drugs or compounds available that directly target ARNT2. However, research into ARNT2-related pathways may lead to the development of novel therapeutic strategies for neurological disorders.

Is ARNT2 associated with any specific brain regions? 01/16/2022

ARNT2 is widely expressed in various regions of the brain, including the cortex, hippocampus, amygdala, and striatum. Its expression patterns suggest involvement in multiple brain functions, including learning, memory, emotion, and motor control.

Is ARNT2 essential for embryonic development? 10/26/2021

Yes, ARNT2 is considered essential for embryonic development. Knockout studies in mice have shown that loss of ARNT2 leads to developmental defects and embryonic lethality.

Can ARNT2 be implicated in neurodevelopmental disorders other than autism spectrum disorders? 03/03/2021

Yes, besides autism spectrum disorders, ARNT2 has also been implicated in other neurodevelopmental disorders such as attention deficit hyperactivity disorder (ADHD), intellectual disabilities, and developmental delay. The specific role of ARNT2 in these conditions is still being investigated.

Does ARNT2 interact with other proteins or signaling pathways? 06/27/2020

Yes, ARNT2 interacts with other proteins and signaling pathways to regulate gene expression. It forms complexes with other transcription factors, such as SIM1, to control target gene activation in specific cell types.

Are there any animal models available for studying ARNT2? 05/17/2020

Yes, animal models have been generated to study the function of ARNT2. Knockout mice lacking ARNT2 exhibit abnormal brain development, cognitive deficits, and altered behavior. These animal models have provided valuable insights into the role of ARNT2 in neuronal function and neurodevelopment.

What are the known functions of ARNT2 in the brain? 03/24/2020

ARNT2 is primarily expressed in the brain and plays important roles in neuronal development, synaptic plasticity, and neuroprotection. It is involved in the regulation of gene expression, particularly genes that are important for neuronal function, such as those involved in synaptic transmission, neurotrophic signaling, and neurotransmitter synthesis.

How is ARNT2 involved in neural development? 09/25/2019

ARNT2 is involved in various aspects of neural development, including neuronal differentiation, axon guidance, synapse formation, and neural circuit formation. It regulates the expression of genes critical for these processes.

Can ARNT2 be involved in the regulation of circadian rhythms? 07/27/2019

Yes, ARNT2 is known to interact with CLOCK/BMAL1, a crucial component of the molecular machinery regulating circadian rhythms. Through this interaction, ARNT2 plays a role in the control of circadian gene expression and the maintenance of proper sleep-wake cycles.

Are there any genetic variations or mutations in the ARNT2 gene associated with human diseases? 07/22/2019

Yes, mutations and genetic variations in the ARNT2 gene have been found in individuals with intellectual disabilities, autism spectrum disorders, developmental delay, and schizophrenia. These variations can lead to altered protein function or expression levels.

Are there any drugs or interventions that can modulate ARNT2 expression or function? 09/17/2018

Currently, there are no known drugs or interventions specifically targeting ARNT2. However, understanding how ARNT2 interacts with other signaling pathways and regulatory factors may provide insights into potential therapeutic approaches in the future.

Are there any genetic disorders associated with mutations in the ARNT2 gene? 09/10/2018

Yes, mutations in the ARNT2 gene have been linked to a rare genetic disorder called Coffin-Siris syndrome (CSS). CSS is characterized by intellectual disability, developmental delay, and distinctive facial features. These mutations can disrupt the function of ARNT2 and its ability to regulate gene expression, leading to the characteristic symptoms of the syndrome.

What are some target genes regulated by ARNT2? 05/05/2018

ARNT2 regulates the expression of various genes involved in neuronal development and function, including BDNF (Brain-Derived Neurotrophic Factor), CAMK2D (Calcium/Calmodulin-Dependent Protein Kinase II Delta), NMDAR1 (N-Methyl-D-Aspartate Receptor 1), and CREB (cAMP response element-binding protein).

What are the developmental stages at which ARNT2 is expressed in the brain? 04/13/2018

ARNT2 is expressed throughout various developmental stages of the brain, from early embryonic stages to adulthood. Its expression levels and patterns can vary across different brain regions and cell types, reflecting its diverse roles in neurodevelopment and neuronal function.

Does ARNT2 play a role in neuronal survival or apoptosis? 11/30/2017

ARNT2 has been shown to play a role in neuronal survival and protection against apoptosis (programmed cell death) in certain conditions. Its activation can promote the survival of neurons under various stress conditions, such as hypoxia or exposure to toxins. However, the underlying mechanisms and specific targets involved in this process require further investigation.

Does ARNT2 have any known roles in cognitive function or behavior? 03/24/2017

Yes, studies have suggested that ARNT2 may play a role in cognitive abilities and behavior. Alterations in ARNT2 expression or mutations in the ARNT2 gene have been associated with intellectual disabilities, autism spectrum disorders, and schizophrenia.

Can ARNT2 interact with other transcription factors? 03/19/2017

Yes, ARNT2 can interact with other transcription factors to regulate gene expression. It forms heterodimers with other basic helix-loop-helix-PAS (bHLH-PAS) family members, such as HIF-1α and HIF-2α, to control the expression of target genes. These interactions are crucial for the transcriptional regulation of ARNT2 target genes.

Are there any studies linking ARNT2 to neuroplasticity? 02/22/2017

Yes, studies have shown that ARNT2 is involved in regulating neuroplasticity, which refers to the brain's ability to adapt and reorganize in response to experiences and learning. ARNT2 is thought to play a role in synaptic plasticity and long-term potentiation (LTP), processes important for learning and memory.

Can ARNT2 be used as a biomarker for any neurological conditions? 01/31/2017

While ARNT2 has been implicated in various neurological conditions, its specific role as a biomarker is still under investigation. Further research is needed to determine its potential usefulness as a diagnostic or prognostic biomarker.

Can ARNT2 be regulated by environmental factors? 12/01/2016

Yes, ARNT2 expression can be influenced by environmental factors such as hypoxia (low oxygen levels) and exposure to certain chemicals. This regulation helps the body adapt to changing environmental conditions.

Can ARNT2 be involved in neurodegenerative diseases? 10/15/2016

While ARNT2's role in neurodegenerative diseases is not well-studied, it is possible that dysregulation of ARNT2 or its target genes could contribute to the pathology of certain neurodegenerative conditions. Further research is needed to explore this potential connection.

Does ARNT2 have any roles in aging or neurodegenerative diseases? 07/03/2016

The role of ARNT2 in aging and neurodegenerative diseases is not well-studied. However, some evidence suggests that ARNT2 expression may decline with age, and dysregulation of ARNT2-mediated gene expression could potentially contribute to age-related cognitive decline or neurodegenerative diseases. Further research is needed to explore this relationship.

Is there any evidence suggesting a role for ARNT2 in neuroprotection? 06/19/2016

While ARNT2's exact role in neuroprotection is not well-understood, studies have shown that it can confer resistance to certain cellular stresses and promote neuronal survival. Further research is needed to determine its specific mechanisms in neuroprotection.

Does ARNT2 have any roles in mood disorders? 01/15/2016

While ARNT2's role in mood disorders is not extensively studied, some research suggests that it may be involved in the development and regulation of mood-related brain regions. Altered ARNT2 expression or dysfunction could potentially contribute to mood disorders, but more research is needed to establish a direct link.

Customer Reviews (6)

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Reviews
12/14/2022

    Its purity and functionality have been extensively tested, ensuring reliable and reproducible results in my research.

    06/28/2022

      One notable advantage of using the ARNT2 protein is the outstanding technical support provided by its manufacturer.

      06/30/2020

        Its exceptional performance in ELISA assays makes it a reliable tool for detecting and quantifying specific target molecules with high sensitivity and specificity.

        09/01/2018

          The ARNT2 protein is of exceptional quality, making it an ideal choice to meet my experimental needs.

          05/12/2017

            the ARNT2 protein has demonstrated its efficacy in protein electron microscopy structure analysis.

            12/01/2016

              The ARNT2 protein comes highly recommended for a variety of research applications.

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