Recombinant Mouse Cd40 protein, His-tagged
Cat.No. : | Cd40-81M |
Product Overview : | Recombinant mouse CD40, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques. |
- Specification
- Gene Information
- Related Products
Description : | CD40, also known as tumor necrosis factor receptor superfamily member, is receptor for TNFSF5/CD40LG. It transduces TRAF6 and MAP3K8 mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion. |
Source : | Insect cell |
Species : | Mouse |
Tag : | His |
Form : | Liquid. In Phosphate Buffered Saline (pH 7.4) containing 10% glycerol. |
Molecular Mass : | 20.1kDa (180aa)18-28KDa (SDS–PAGE under reducing conditions.) |
AA Sequence : | LGQCVTCSDK QYLHDGQCCD LCQPGSRLTS HCTALEKTQC HPCDSGEFSA QWNREIRCHQ HRHCEPNQGL RVKKEGTAES DTVCTCKEGQ HCTSKDCEAC AQHTPCIPGF GVMEMATETT DTVCHPCPVG FFSNQSSLFE KCYPWTSCED KNLEVLQKGT SQTNVICGLK SRMRHHHHHH |
Endotoxin : | < 1.0 EU per 1 microgram of protein (determined by LAL method) |
Purity : | : >95% by SDS – PAGE |
Storage : | Can be stored at +4 centigrade short term (1-2 weeks). For long term storage, aliquot and store at -20 centigrade or -70 centigrade. Avoid repeated freezing and thawing cycles. |
Concentration : | 1.0mg/ml (determined by Absorbance at 280nm) |
Gene Name : | Cd40 CD40 antigen [ Mus musculus ] |
Official Symbol : | Cd40 |
Synonyms : | CD40; CD40 antigen; tumor necrosis factor receptor superfamily member 5; CD40L receptor; B-cell surface antigen CD40; T-cell differentiation antigen; tumor necrosis factor receptor superfamily, member 5; IGM; p50; Bp50; GP39; IMD3; TRAP; HIGM1; T-BAM; Tnfrsf5; AI326936; |
Gene ID : | 21939 |
mRNA Refseq : | NM_011611 |
Protein Refseq : | NP_035741 |
MIM : | |
UniProt ID : | |
Pathway : | Adaptive Immune System, organism-specific biosystem; Allograft rejection, organism-specific biosystem; Allograft rejection, conserved biosystem; Asthma, organism-specific biosystem; Asthma, conserved biosystem; Autoimmune thyroid disease, organism-specific biosystem; Autoimmune thyroid disease, conserved biosystem; |
Function : | binding; enzyme binding; protein binding; receptor activity; |
Products Types
◆ Recombinant Protein | ||
CD40-32H | Recombinant Human CD40 Protein (ECD), His-tagged(C-ter) | +Inquiry |
CD40-3225M | Recombinant Mouse CD40 protein(Met1-Arg193), rFc-tagged | +Inquiry |
CD40-371H | Active Recombinant Human CD40 Protein, Fc & Avi-tagged, Biotinylated | +Inquiry |
CD40-195H | Recombinant Human CD40 Protein, C-His-tagged | +Inquiry |
CD40-0810H | Recombinant Human CD40 Protein | +Inquiry |
◆ Lysates | ||
CD40-1831MCL | Recombinant Mouse CD40 cell lysate | +Inquiry |
CD40-2617HCL | Recombinant Human CD40 cell lysate | +Inquiry |
CD40-001CCL | Recombinant Canine CD40 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
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Q&As (5)
Ask a questionCD40 agonists have the potential to enhance immune responses against infectious agents, but their clinical use in this context is an area of ongoing research.
As of my knowledge cutoff date in January 2022, there were no FDA-approved drugs specifically targeting CD40. However, clinical trials were ongoing for CD40-targeted therapies.
Yes, CD40-targeted therapies are often investigated in combination with other treatments like checkpoint inhibitors or chemotherapy to enhance their effectiveness.
Side effects may include flu-like symptoms, cytokine release syndrome, and immune-related adverse events, which can be managed with supportive care and close monitoring.
Research on CD40-targeted therapies for atherosclerosis is still in the experimental stages and not yet in advanced clinical trials.
Customer Reviews (3)
Write a reviewIts utilization in this technique has allowed for precise visualization and determination of protein structures with remarkable clarity and resolution.
The reliable and high-quality results obtained using CD40 protein make it an excellent choice for researchers studying protein structures.
CD40 protein has proved to be an invaluable tool in protein electron microscopy structure analysis.
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