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Recombinant Mouse Cdh1 protein, His-tagged

Cat.No. : Cdh1-580M
Product Overview : Recombinant Mouse Cdh1 (P09803) aa. (Arg153~Phe264) fused with N-terminal His tag was produced in E. coli cells.
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  • Gene Information
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Description : This gene encodes E-cadherin, a calcium-dependent cell adhesion molecule that functions in the establishment and maintenance of epithelial cell morphology during embryongenesis and adulthood. The encoded preproprotein undergoes proteolytic processing to generate a mature protein. Targeted mutations disrupting binding of calcium to the encoded protein in mice cause death in utero due to failed blastocyst and trophectoderm formation. This gene is located adjacent to a related cadherin gene on chromosome 8.
Source : E. coli
Species : Mouse
Tag : His
Form : Freeze-dried powder
Molecular Mass : 14 kDa as determined by SDS-PAGE reducing conditions
Protein length : Arg153~Phe264 (Accession # P09803)
Endotoxin : <1.0EU per 1µg (determined by the LAL method)
Purity : > 95%
Characteristic : The isoelectric point is 6.
Applications : SDS-PAGE; WB; ELISA; IP.
Stability : The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Storage : Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
Storage buffer : PBS, pH7.4, containing 5% sucrose, 0.01% sarcosyl.
Reconstitution : Reconstitute in sterile PBS, pH7.2-pH7.4
Gene Name : Cdh1 cadherin 1 [ Mus musculus (house mouse) ]
Official Symbol : Cdh1
Synonyms : Cdh1; cadherin 1; Um; UVO; Ecad; ARC-1; E-cad; L-CAM; AA960649; E-cadherin; epithelial cadherin; uvomorulin; cadherin-1
Gene ID : 12550
mRNA Refseq : NM_009864.3
Protein Refseq : NP_033994.1
UniProt ID : P09803

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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How about the inheritance pattern of CDH1 gene mutations? 09/25/2019

CDH1 gene mutations are usually passed on in an autosomal dominant manner, depending on the type and location of the mutation.

What screening is required for carriers of CDH1 gene mutations? 08/03/2019

Carriers of CDH1 gene mutations should have gastroscopy, ultrasonography, and other related tests to monitor the development and progression of stomach cancer.

Can CDH1 gene mutations be prevented or treated? 06/14/2019

For people with mutations in the CDH1 gene, prophylactic total gastrectomy may reduce the risk of diffuse stomach cancer. There is currently no specific treatment to target CDH1 gene mutations.

Which gastric cancer subtypes are associated with CDH1 mutations? 04/21/2019

CDH1 gene mutation is closely related to the occurrence of diffuse gastric cancer, which is a special subtype of gastric cancer with a high degree of invasion and malignancy.

What are the effects of CDH1 gene mutations on cell adhesion and tissue differentiation? 04/01/2019

The CDH1 gene encodes a protein called E-calcin that plays an important role in cell adhesion and tissue differentiation. Mutations in the CDH1 gene may affect these processes, resulting in abnormal cell adhesion and tissue differentiation.

What is the relationship between CDH1 gene mutations and breast cancer? 03/24/2019

CDH1 gene mutations may be associated with the development of a small number of breast cancers, because CDH1 also plays a role in regulating cell adhesion and tissue structure in breast tissue.

Customer Reviews (3)

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Reviews
04/22/2022

    This recombinant protein has a very short half-life and shows a very high clearance rate, which makes its biological activity more stable.

    05/27/2020

      The protein was highly purified and was not doped with other proteins or impurities.

      05/21/2019

        CDH1 has similar activity to the native protein and is able to perform the expected biological functions.

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