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Recombinant Mouse Crlf2 protein, Fc-tagged

Cat.No. : Crlf2-451M
Product Overview : Recombinant Mouse Crlf2(Ala20-Leu233) fused with Fc tag at C-terminal was expressed in HEK293.
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Description : The cytokine thymic stromal lymphopoietin receptor (TSLPR) is consisting of a common γ receptor–like chain (TSLPR-γ) and a common interleukin 7 (IL-7) Rα chain that belongs to the type 1 cytokine receptor family. Transfection of TSLPR cDNA result in only low affinity binding, while cotransfection of the IL-7Rα chain cDNA shows high affinity binding. TSLP and TSLPR play a critical role in the initiation of allergic diseases in mice. The TSLP R cDNA encodes a transmembrane receptor containing 370 amino acids (aa) with two potential N-linked glycosylation sites and a cytoplasmic domain of 104 aa including a single tyrosine residue. TSLPR can mediate signaling of the signal transducer and activator of transcription 5 (Stat5) by TSLP. TSLP R is broadly expressed in the immune and hematopoietic cells, particularly in hematopoietic progenitors and myeloid cells.
Source : HEK293
Species : Mouse
Tag : Fc
Form : Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
Protein length : Ala20-Leu233
AA Sequence : AAAVTSRGDVTVVCHDLETVEVTWG SGPDHHSANLSLEFRYGTGALQPCP RYFLSGAGVTSGCIL PAARAGLLELALRDGGGAMVFKARQ RASAWLKPRPPWNVTLLWTPDGDVT VSWPAHSYLGLDYEV QHRESNDDEDAWQTTSGPCCDLTVG GLDPARCYDFRVRASPRAAHYGLEA QPSEWTAVTRLSGAA SAASCTASPAPSPALAPPLVDDIEG RMDEPKSCDKTHTCPPCPAPELLGG PSVFLFPPKPKDTLM ISRTPEVTCVVVDVSHEDPEVKFNW YVDGVEVHNAKTKPREEQYNSTYRV VSVLTVLHQDWLNGK EYKCKVSNKALPAPIEKTISKAKGQ PREPQVYTLPPSREEMTKNQVSLTC LVKGFYPSDIAVEWE SNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFSCSVMHEAL HNHYTQKSLSLSPGK
Endotoxin : Less than 0.1 ng/?g (1 IEU/?g) as determined by LAL test.
Purity : Greater than 95% as determined by reducing SDS-PAGE.
Storage : Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7°C for 2-7 days.Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Reconstitution : Always centrifuge tubes before opening. Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in ddH2O.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
Shipping : The product is shipped at ambient temperature.
Gene Name : Crlf2 cytokine receptor-like factor 2 [ Mus musculus ]
Official Symbol : Crlf2
Synonyms : CRLF2; cytokine receptor-like factor 2; CRLM-2; delta 1; TSLP receptor; lymphocyte antigen 114; type I cytokine receptor delta 1; cytokine receptor-like molecule 2; thymic stromal lymphopoietin protein receptor; thymic stromal-derived lymphopoietin, receptor; transmembrane phosphoinositide 3-phosphatase and tensin homolog 2; CRLM2; Ly114; Tpte2; Tslpr;
Gene ID : 57914
mRNA Refseq : NM_001164735
Protein Refseq : NP_001158207
UniProt ID : Q8CII9
Chromosome Location : 5; 5 F
Pathway : Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Jak-STAT signaling pathway, organism-specific biosystem; Jak-STAT signaling pathway, conserved biosystem;
Function : cytokine activity; receptor activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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How does CRLF2 protein interact with other proteins? 05/11/2023

The protein may interact with other proteins to fulfill its function. These interactions can involve various types of protein-protein interactions like electrostatic interactions, hydrogen bonding, etc. Understanding these interactions can help unravel the mechanism of action of the CRLF2 protein in cells.

How is the expression level of CRLF2 protein regulated? 07/30/2022

The expression level of CRLF2 protein may be regulated by a variety of factors, including gene transcription, translation, post-transcriptional modification, etc. Studying these regulatory mechanisms can help to understand the expression patterns of CRLF2 protein in organisms and its impact on biological processes.

What are the effects of mutations or modifications in the CRLF2 protein on organisms? 10/30/2021

Mutations or modifications of the CRLF2 protein may affect its function and thus affect the organism. The specific effects may vary depending on the type and location of the mutation or modification and may involve various biological processes, such as growth and development, immune response, etc.

In which biological processes does CRLF2 protein play a role? 10/21/2021

CRLF2 protein may be involved in a variety of biological processes, including immune response, regulation of hematopoietic processes, cell growth and differentiation, etc. These processes require the regulatory effect of CRLF2 protein for normal life activities.

What is the structure and function of CRLF2 protein? 04/04/2021

Studying the structure and function of CRLF2 protein may require the design of a series of experiments, including biochemical and cell biology experiments. For example, X-ray crystal diffraction can be used to study its structure, and its function can be studied by gene knockout or knockdown techniques.

How to evaluate the potential of CRLF2 protein as a drug target? 12/29/2020

Evaluating the potential of CRLF2 protein as a drug target may involve several aspects, including its expression level in organisms, its role in biological processes, and its changes in disease. In addition, factors such as ease of drug development for this protein and potential drug side effects need to be considered. At the same time, in vitro and in vivo experiments can be performed with known CRLF2 inhibitors or agonists to verify their efficacy and safety.

Customer Reviews (3)

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Reviews
03/02/2023

    CRLF2 is highly expressed, which is convenient for detection and quantification.

    06/11/2022

      Green and pollution-free, it can be seen that the manufacturer is very environmentally conscious.

      10/01/2020

        The range of applications is breathtaking, and it can play an important role in any field.

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