Recombinant Mouse Csf2 protein, His/S-tagged
Cat.No. : | Csf2-223M |
Product Overview : | Recombinant Mouse Csf2 fused with His/S tag was expressed in E. coli. |
- Specification
- Gene Information
- Related Products
Description : | Granulocyte-macrophage colony-stimulating factor (GM-CSF) is one of an array of cytokines with pivotal roles in embryo implantation and subsequent development. Several cell lineages in the reproductive tract and gestational tissues synthesise GM-CSF under direction by ovarian steroid hormones and signalling agents originating in male seminal fluid and the conceptus. The pre-implantation embryo, invading placental trophoblast cells and the abundant populations of leukocytes controlling maternal immune tolerance are all subject to GM-CSF regulation. GM-CSF stimulates the differentiation of hematopoietic progenitors to monocytes and neutrophils, and reduces the risk for febrile neutropenia in cancer patients. GM-CSF also has been shown to induce the differentiation of myeloid dendritic cells (DCs) that promote the development of T-helper type 1 (cellular) immune responses in cognate T cells. The active form of the protein is found extracellularly as a homodimer, and the encoding gene is localized to a related gene cluster at chromosome region 5q31 which is known to be associated with 5q-syndrome and acute myelogenous leukemia. As a part of the immune/inflammatory cascade, GM-CSF promotes Th1 biased immune response, angiogenesis, allergic inflammation, and the development of autoimmunity, and thus worthy of consideration for therapeutic target. GM-CSF has been utilized in the clinical management of multiple disease processes. Most recently, GM-CSF has been incorporated into the treatment of malignancies as a sole therapy, as well as a vaccine adjuvant. While the benefits of GM-CSF in this arena have been promising, recent reports have suggested the potential for GM-CSF to induce immune suppression and, thus, negatively impact outcomes in the management of cancer patients. GM-CSF deficiency in pregnancy adversely impacts fetal and placental development, as well as progeny viability and growth after birth, highlighting this cytokine as a central maternal determinant of pregnancy outcome with clinical relevance in human fertility. |
Source : | E. coli |
Species : | Mouse |
Tag : | His/S |
Form : | Lyophilized from sterile PBS, pH 7.4 |
Purity : | > 95 % as determined by SDS-PAGE |
Storage : | Store at -70 centigrade. Avoid repeated freeze/thaw cycles. |
Gene Name : | Csf2 colony stimulating factor 2 (granulocyte-macrophage) [ Mus musculus ] |
Official Symbol : | Csf2 |
Synonyms : | CSF2; colony stimulating factor 2 (granulocyte-macrophage); granulocyte-macrophage colony-stimulating factor; CSF; put. GM-CSF; colony-stimulating factor; granulocyte-macrophage colony stimulating factor 2; Csfgm; GMCSF; Gm-CSf; MGI-IGM; MGC151255; MGC151257; |
Gene ID : | 12981 |
mRNA Refseq : | NM_009969 |
Protein Refseq : | NP_034099 |
UniProt ID : | P01587 |
Chromosome Location : | 11 B1.3; 11 32.13 cM |
Pathway : | Amoebiasis, organism-specific biosystem; Amoebiasis, conserved biosystem; Cytokine Signaling in Immune system, organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Cytokines and Inflammatory Response (BioCarta), organism-specific biosystem; Fc epsilon RI signaling pathway, organism-specific biosystem; |
Function : | cytokine activity; cytokine activity; granulocyte macrophage colony-stimulating factor receptor binding; growth factor activity; |
Products Types
◆ Recombinant Protein | ||
CSF2-207P | Active Recombinant Pig CSF2 Protein (Ala18-Lys144), N-His tagged, Animal-free, Carrier-free | +Inquiry |
CSF2-492H | Recombinant Human CSF2 Protein, Biotinylated | +Inquiry |
Csf2-4346R | Recombinant Rat Csf2 Protein | +Inquiry |
CSF2-4343O | Recombinant Ovine CSF2 Protein | +Inquiry |
CSF2-3350H | Recombinant Human CSF2 Protein, MYC/DDK-tagged | +Inquiry |
◆ Lysates | ||
CSF2-3008HCL | Recombinant Human CSF2 cell lysate | +Inquiry |
CSF2-1008MCL | Recombinant Mouse CSF2 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
0
Inquiry Basket