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Recombinant Mouse Cul3 protein, His-tagged

Cat.No. : CUL3-4077M
Product Overview : Recombinant Mouse Cul3(2-768 aa) fused with His tag was expressed in E. coli.
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  • Gene Information
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Description : Cul3 played an important role in many functions.
Source : E. coli
Species : Mouse
Tag : His
Form : Tris-based buffer,50% glycerol
Protein length : 2-768 aa
AA Sequence : SNLSKGTGS RKDTKMRIRA FPMTMDEKYV NSIWDLLKNA IQEIQRKNNS GLSFEELYRN AYTMVLHKHG EKLYTGLREV VTEHLINKVR EDVLNSLNNN FLQTLNQAWN DHQTAMVMIR DILMYMDRVY VQQNNVENVY NLGLIIFRDQ VVRYGCIRDH LRQTLLDMIA RERKGEVVDR GAIRNACQML MILGLEGRSV YEEDFEAPFL EMSAEFFQME SQKFLAENSA SVYIKKVEAR INEEIERVMH CLDKSTEEPI VKVVERELIS KHMKTIVEME NSGLVHMLKN GKTEDLACMY KLFSRVPNGL KTMCECMSCY LREQGKALVS EEGEGKNPVD YIQGLLDLKS RFDRFLQESF NNDRLFKQTI AGDFEYFLNL NSRSPEYLSL FIDDKLKKGV KGLTEQEVET ILDKAMVLFR FMQEKDVFER YYKQHLARRL LTNKSVSDDS EKNMISKLKT ECGCQFTSKL EGMFRDMSIS NTTMDEFRQH LQATGVSLGG VDLTVRVLTT GYWPTQSATP KCNIPPAPRH AFEIFRRFYL AKHSGRQLTL QHHMGSADLN ATFYGPVKKE DGSEVGVGGA QVTGSNTRKH ILQVSTFQMT ILMLFNNREK YTFEEIQQET DIPERELVRA LQSLACGKPT QRVLTKEPKS KEIESGHIFT VNDQFTSKLH RVKIQTVAAK QGESDPERKE TRQKVDDDRK HEIEAAIVRI MKSRKKMQHN VLVAEVTQQL KARFLPSPVV IKKRIEGLIE REYLARTPED RKVYTYVA
Purity : >90% ( SDS-PAGE )
Notes : Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week.
Storage : Store at -20 centigrade, for extended storage, conserve at -20 centigrade or -80 centigrade.
Gene Name : Cul3 cullin 3 [ Mus musculus ]
Official Symbol : Cul3
Synonyms : CUL3; cullin 3; cullin-3; CUL-3; AI467304; AW146203; mKIAA0617;
Gene ID : 26554
mRNA Refseq : NM_016716
Protein Refseq : NP_057925
UniProt ID : Q9JLV5
Chromosome Location : 1; 1 C4
Pathway : Cul3-SPOP complex, organism-specific biosystem; Ubiquitin mediated proteolysis, organism-specific biosystem; Ubiquitin mediated proteolysis, conserved biosystem;
Function : cyclin binding; ubiquitin protein ligase binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Can CUL3 protein be targeted for drug development? 07/30/2020

Yes, targeting CUL3 as a therapeutic strategy is being explored, particularly in the context of cancer and neurodegenerative diseases.

How can CUL3 protein be used as a biomarker for disease diagnosis? 06/29/2020

Elevated levels of CUL3 protein expression have been observed in certain types of cancer, suggesting its potential as a biomarker for cancer diagnosis and prognosis.

How does CUL3 interact with other proteins in the cell? 03/26/2020

CUL3 forms complexes with various substrate receptors and adaptor proteins, allowing it to target specific proteins for degradation via the ubiquitin-proteasome system.

How can CUL3 mutations impact drug response and resistance? 07/15/2018

CUL3 mutations may affect the response to certain cancer therapies by altering the degradation of drug targets, potentially leading to drug resistance.

Are there any specific diseases associated with CUL3 mutations? 10/05/2016

Yes, mutations in the CUL3 gene have been linked to a rare genetic disorder called pseudohypoaldosteronism type II (PHAII), which affects the regulation of blood pressure and electrolyte balance.

Customer Reviews (3)

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Reviews
12/01/2021

    Its superior purity and stability ensure reliable and accurate results, instilling confidence in my research.

    06/09/2020

      Whether I am studying protein interactions, cellular localization, or signaling pathways, the CUL3 protein consistently delivers reliable and reproducible data, enabling significant scientific advancements.

      10/14/2016

        Their assistance has been invaluable in streamlining my experiments and overcoming obstacles effectively.

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