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Recombinant Mouse Dnajb1 protein, His & T7-tagged

Cat.No. : Dnajb1-7863M
Product Overview : Recombinant Mouse Dnajb1 aa. (Gly2~Ile340 (Accession# Q9QYJ3)) fused with N-terminal His & T7 tag was produced in E. coli cells.
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  • Gene Information
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Description : This gene encodes a member of the DnaJ or Hsp40 (heat shock protein 40 kD) family of proteins. The encoded protein is a molecular chaperone that stimulates the ATPase activity of Hsp70 heat-shock proteins in order to promote protein folding and prevent misfolded protein aggregation. The encoded protein may also inhibit apoptosis. Peritoneal macrophages derived from homozygous knockout mice for this gene exhibit impaired heat tolerance. Alternative splicing results in multiple transcript variants.
Source : E. coli
Species : Mouse
Tag : His & T7
Form : Freeze-dried powder
Molecular Mass : Predicted Molecular Mass: 41.7kDa
Protein length : Gly2~Ile340 (Accession# Q9QYJ3)
Endotoxin : <1.0EU per 1µg (determined by the LAL method)
Purity : >95%
Characteristic : The isoelectric point is 8.8.
Applications : SDS-PAGE; WB; ELISA; IP
Stability : The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Storage : Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
Storage buffer : Supplied as lyophilized form in PBS, pH7.4, containing 5% trehalose, 0.01% sarcosyl
Reconstitution : Reconstitute in sterile PBS, pH7.2-pH7.4.
Gene Name : Dnajb1 DnaJ heat shock protein family (Hsp40) member B1 [ Mus musculus (house mouse) ]
Official Symbol : Dnajb1
Synonyms : Dnajb1; DnaJ heat shock protein family (Hsp40) member B1; DjB1; Hdj1; HSPF1; Hsp40; 0610007I11Rik; dnaJ homolog subfamily B member 1; DnaJ (Hsp40) homolog, subfamily B, member 1; heat shock 40 kDa protein 1
Gene ID : 81489
mRNA Refseq : NM_018808.3
Protein Refseq : NP_061278.1
UniProt ID : Q9QYJ3

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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How does DNAJB1 contribute to the pathogenesis of neurodegenerative diseases, such as Alzheimer's and Parkinson's? 05/30/2022

DNAJB1 plays a role in neurodegenerative diseases by influencing the handling of misfolded proteins in neurons.

How does DNAJB1 influence the immune response, especially in regulating inflammation and immune cell function? 05/26/2021

DNAJB1 modulates the immune system, particularly in controlling inflammation and immune cell responses.

How does DNAJB1 assist in protein folding and prevent misfolding or aggregation of proteins within cells? 05/16/2021

DNAJB1 aids in protein folding and prevents the aggregation of misfolded proteins, crucial for maintaining cellular proteostasis.

What are the mechanisms by which DNAJB1 modulates apoptosis and cell survival under stress? 02/11/2021

DNAJB1 regulates apoptosis and cell survival, especially under conditions of cellular stress.

What is the impact of DNAJB1 on cancer cell survival, proliferation, and response to chemotherapy? 09/06/2019

DNAJB1 affects cancer cell behavior, influencing tumor growth, survival, and sensitivity to treatments.

What role does DNAJB1 play in cellular responses to heat shock and other stress conditions? 05/08/2019

DNAJB1 is key in cellular stress responses, particularly to heat shock, by stabilizing proteins and aiding in recovery.

How do alterations in DNAJB1 expression or function affect muscle cell health and the development of muscular disorders? 10/04/2018

Changes in DNAJB1 expression impact muscle cell function and health, potentially contributing to muscular disorders.

Customer Reviews (3)

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Reviews
07/15/2022

    Efficient peptide synthesis, crucial for advancing our peptide research.

    07/21/2021

      Exceptional protein engineering services, a vital resource for our lab.

      11/26/2020

        Reliable protein crystallography, a crucial part of structural research.

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