Recombinant Mouse Esr1 protein, His & GST-tagged
Cat.No. : | Esr1-1438M |
Product Overview : | Recombinant Mouse Esr1 aa. (Ile233~Leu483) fused with N-terminal His & GST tag was produced in E. coli cells. |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes an estrogen receptor, a member of the nuclear hormone family of intracellular receptors. The encoded protein, activated by the sex hormone estrogen, is a transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Similar genes in human have been implicated in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative splicing results in multiple transcript variants. |
Source : | E. coli |
Species : | Mouse |
Tag : | His & GST |
Form : | Freeze-dried powder |
Molecular Mass : | 59kDa as determined by SDS-PAGE reducing conditions. |
Protein length : | Ile233~Leu483 |
Endotoxin : | <1.0EU per 1µg (determined by the LAL method). |
Purity : | >95% |
Characteristic : | The isoelectric point is 9. |
Applications : | SDS-PAGE; WB; ELISA; IP; CoIP; Purification; Amine Reactive Labeling |
Stability : | The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition. |
Storage : | Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months. |
Concentration : | 200µg/mL |
Storage buffer : | 20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% sarcosyl, 5%Trehalose and Proclin300. |
Reconstitution : | Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0mg/mL. Do not vortex. |
Gene Name : | Esr1 estrogen receptor 1 (alpha) [ Mus musculus (house mouse) ] |
Official Symbol : | Esr1 |
Synonyms : | ER; ERa; ESR; Estr; Estra; Nr3a1; ERalpha; ER-alpha; C-terminally-truncated estrogen receptor alpha product-4; C-terminally-truncated estrogen receptor alpha product-5; C-terminally-truncated estrogen receptor alpha product-6; C-terminally-truncated estrogen receptor alpha product-7; estradiol receptor; nuclear receptor subfamily 3 group A member 1; estrogen receptor |
Gene ID : | 13982 |
mRNA Refseq : | NM_001302531.1 |
Protein Refseq : | NP_001289460.1 |
UniProt ID : | P19785 |
Products Types
◆ Recombinant Protein | ||
ESR1-1390H | Recombinant Human ESR1 Protein (10-595 aa), His-tagged | +Inquiry |
Esr1-977M | Recombinant Mouse Esr1 Protein, MYC/DDK-tagged | +Inquiry |
ESR1-1808R | Recombinant Rat ESR1 Protein, His (Fc)-Avi-tagged | +Inquiry |
ESR1-02H | Recombinant Human ESR1 Protein, His-tagged | +Inquiry |
ESR1-2534H | Recombinant Human ESR1 protein(191-270 aa), C-His-tagged | +Inquiry |
◆ Lysates | ||
ESR1-6540HCL | Recombinant Human ESR1 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionESR1 mutations can lead to resistance to endocrine therapies in breast cancer patients, impacting treatment outcomes.
ESR1 testing can provide important prognostic information by helping to predict the likelihood of a favorable response to hormone therapy.
ESR1 protein can be detected through various laboratory techniques, including immunohistochemistry (IHC) and immunoblotting.
Research is ongoing, and there are efforts to develop targeted therapies for ESR1-mutated breast cancer, but it's still an evolving field.
ESR1 status is determined through the examination of tumor tissue samples, often using IHC or molecular testing.
Customer Reviews (3)
Write a reviewIts high specificity and robust activity make it an ideal candidate for investigating intricate molecular interactions and elucidating complex biological mechanisms.
Tthe manufacturer's commitment to exceptional technical support offers me peace of mind, knowing that any challenges or concerns I may encounter will be effectively addressed. he manufacturer's commitment to exceptional technical support offers me peace of mind, knowing that any challenges or concerns I may encounter will be effectively addressed.
With the ESR1 protein, I can confidently pursue my scientific objectives and overcome experimental obstacles, enabling me to make significant strides in my field of study.
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