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Recombinant Mouse Esr1 protein, His & GST-tagged

Cat.No. : Esr1-1438M
Product Overview : Recombinant Mouse Esr1 aa. (Ile233~Leu483) fused with N-terminal His & GST tag was produced in E. coli cells.
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  • Gene Information
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Description : This gene encodes an estrogen receptor, a member of the nuclear hormone family of intracellular receptors. The encoded protein, activated by the sex hormone estrogen, is a transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Similar genes in human have been implicated in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative splicing results in multiple transcript variants.
Source : E. coli
Species : Mouse
Tag : His & GST
Form : Freeze-dried powder
Molecular Mass : 59kDa as determined by SDS-PAGE reducing conditions.
Protein length : Ile233~Leu483
Endotoxin : <1.0EU per 1µg (determined by the LAL method).
Purity : >95%
Characteristic : The isoelectric point is 9.
Applications : SDS-PAGE; WB; ELISA; IP; CoIP; Purification; Amine Reactive
Labeling
Stability : The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Storage : Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
Concentration : 200µg/mL
Storage buffer : 20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% sarcosyl, 5%Trehalose and Proclin300.
Reconstitution : Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0mg/mL. Do not vortex.
Gene Name : Esr1 estrogen receptor 1 (alpha) [ Mus musculus (house mouse) ]
Official Symbol : Esr1
Synonyms : ER; ERa; ESR; Estr; Estra; Nr3a1; ERalpha; ER-alpha; C-terminally-truncated estrogen receptor alpha product-4; C-terminally-truncated estrogen receptor alpha product-5; C-terminally-truncated estrogen receptor alpha product-6; C-terminally-truncated estrogen receptor alpha product-7; estradiol receptor; nuclear receptor subfamily 3 group A member 1; estrogen receptor
Gene ID : 13982
mRNA Refseq : NM_001302531.1
Protein Refseq : NP_001289460.1
UniProt ID : P19785

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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What are the clinical implications of ESR1 mutations in breast cancer? 04/13/2023

ESR1 mutations can lead to resistance to endocrine therapies in breast cancer patients, impacting treatment outcomes.

How does ESR1 testing impact the prognosis of breast cancer patients? 10/02/2022

ESR1 testing can provide important prognostic information by helping to predict the likelihood of a favorable response to hormone therapy.

How is ESR1 protein detected in clinical practice? 09/27/2021

ESR1 protein can be detected through various laboratory techniques, including immunohistochemistry (IHC) and immunoblotting.

Can ESR1 mutations be targeted in breast cancer treatment? 02/23/2021

Research is ongoing, and there are efforts to develop targeted therapies for ESR1-mutated breast cancer, but it's still an evolving field.

How is ESR1 status determined in breast cancer patients? 05/05/2019

ESR1 status is determined through the examination of tumor tissue samples, often using IHC or molecular testing.

Customer Reviews (3)

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Reviews
05/30/2021

    Its high specificity and robust activity make it an ideal candidate for investigating intricate molecular interactions and elucidating complex biological mechanisms.

    04/24/2019

      Tthe manufacturer's commitment to exceptional technical support offers me peace of mind, knowing that any challenges or concerns I may encounter will be effectively addressed. he manufacturer's commitment to exceptional technical support offers me peace of mind, knowing that any challenges or concerns I may encounter will be effectively addressed.

      12/08/2017

        With the ESR1 protein, I can confidently pursue my scientific objectives and overcome experimental obstacles, enabling me to make significant strides in my field of study.

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