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Recombinant Mouse Fgf2 protein, His/S-tagged

Cat.No. : Fgf2-199M
Product Overview : Recombinant Mouse Fgf2 fused with His/S tag was expressed in E. coli.
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  • Gene Information
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Description : The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members bind heparin and possess broad mitogenic and angiogenic activities. This protein has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth. The mRNA for this gene contains multiple polyadenylation sites, and is alternatively translated from non-AUG (CUG) and AUG initiation codons, resulting in five different isoforms with distinct properties. The CUG-initiated isoforms are localized in the nucleus and are responsible for the intracrine effect, whereas, the AUG-initiated form is mostly cytosolic and is responsible for the paracrine and autocrine effects of this FGF.
Source : E. coli
Species : Mouse
Tag : His/S
Form : Lyophilized from sterile PBS, pH 7.4
Purity : > 95 % as determined by SDS-PAGE
Storage : Store at -70 centigrade. Avoid repeated freeze/thaw cycles.
Gene Name : Fgf2 fibroblast growth factor 2 [ Mus musculus ]
Official Symbol : Fgf2
Synonyms : FGF2; fibroblast growth factor 2; HBGF-2; basic fibroblast growth factor; heparin-binding growth factor 2; Fgfb; bFGF; Fgf-2;
Gene ID : 14173
mRNA Refseq : NM_008006
Protein Refseq : NP_032032
UniProt ID : P15655
Chromosome Location : 3 B; 3 18.41 cM
Pathway : Downstream signaling of activated FGFR, organism-specific biosystem; ESC Pluripotency Pathways, organism-specific biosystem; Endochondral Ossification, organism-specific biosystem; FGFR ligand binding and activation, organism-specific biosystem; FGFR1 ligand binding and activation, organism-specific biosystem; FGFR1b ligand binding and activation, organism-specific biosystem; FGFR1c ligand binding and activation, organism-specific biosystem;
Function : chemoattractant activity; cytokine activity; fibroblast growth factor binding; fibroblast growth factor receptor binding; fibroblast growth factor receptor binding; growth factor activity; growth factor activity; heparin binding; ligand-dependent nuclear receptor transcription coactivator activity; protein binding; voltage-gated calcium channel activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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What is the biological function of FGF2? 11/10/2022

FGF2 promotes cell migration and angiogenesis and regulates bone homeostatic balance.

Where is FGF2 mainly expressed? 10/22/2022

FGF2 is widely expressed in the nervous system.

In which tissues of sheep is FGF2 primarily expressed? 01/01/2022

FGF2 is mainly expressed in tissues such as mammary glands and ovaries of sheep.

What protein does FGF2 share high homology with? 03/08/2021

FGF1 has a high degree of homology with FGF2.

What diseases is FGF2 involved in? 02/12/2021

FGF2 is involved in diseases such as cardiovascular disease, breast disease and bone homeostasis.

How does FGF2 regulate bone homeostasis? 11/21/2020

FGF2 negatively regulates bone homeostasis.

Customer Reviews (2)

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Reviews
07/14/2022

    The technical expert communicated with me in time to understand the progress of my experiment and gave me suggestions for improvement.

    02/04/2022

      The purchased protein is suitable for WB experiments and I am satisfied with the results.

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