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Active Recombinant Mouse IL2 Protein

Cat.No. : IL2-955M
Product Overview : Recombinant soluble form of mouse IL2 (P04351) (Ala 21-Gln 169) was expressed, with an initial Met at the C-terminus.
  • Specification
  • Gene Information
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Source : E. coli
Species : Mouse
Predicted N Terminal : Met
Form : Lyophilized from sterile PBS, 2mM DTT, pH 7.4, 5%~8% trehalose and mannitol.
Bio-activity : 1. Measured by its ability to bind recombinant human IL2Ra-Fc in a functional ELISA. 2. Measured in a cell proliferation assay using CTLL2. The ED50 for this effect is typically 0.2-1.0 ng/mL.
Molecular Mass : The recombinant mouse IL2 consists of 150 amino acids and has a calculated molecular mass of 17.4KDa. It migrates as an approximately 19 kDa in SDS-PAGE under reducing conditions.
Endotoxin : < 1.0 EU per μg of the protein as determined by the LAL method.
Purity : >92 % as determined by SDS-PAGE.
Stability : Samples are stable for up to twelve months from date of receipt at -70ºC.
Storage : Store it under sterile conditions at -20ºC~-70ºC. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.25 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents.
Gene Name : Il2 interleukin 2 [ Mus musculus ]
Official Symbol : IL2
Synonyms : IL2; interleukin 2; interleukin-2; TCGF; T-cell growth factor; Il-2;
Gene ID : 16183
mRNA Refseq : NM_008366
Protein Refseq : NP_032392
MIM :
UniProt ID :
Pathway : Allograft rejection, organism-specific biosystem; Allograft rejection, conserved biosystem; Autoimmune thyroid disease, organism-specific biosystem; Autoimmune thyroid disease, conserved biosystem; Chagas disease (American trypanosomiasis), organism-speci
Function : carbohydrate binding; cytokine activity; cytokine activity; cytokine activity; glycosphingolipid binding; growth factor activity; interleukin-2 receptor binding; interleukin-2 receptor binding; kappa-type opioid receptor binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (10)

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What is the impact of IL2 on T-cell memory formation? 04/25/2022

IL2 promotes the formation of memory T-cells.

What is the role of IL2 in the tumor microenvironment? 12/12/2021

IL2 has a pro-tumorigenic role in the tumor microenvironment.

How does IL2 interact with other cytokines in a mixed environment? 11/22/2021

IL2 synergizes with IL-12 in a mixed cytokine environment.

Does IL2 modulate the expression of checkpoint inhibitors? 06/03/2020

IL2 upregulates the expression of PD-1 checkpoint inhibitors.

What are the kinetics of IL2 internalization in T cells? 08/18/2019

IL2 is rapidly internalized by activated T-cells.

Does IL2 influence the polarization of macrophages? 07/24/2019

IL2 induces M1 macrophage polarization.

How does IL2 affect the blood-brain barrier permeability? 07/06/2018

IL2 increases blood-brain barrier permeability.

How does IL2's affinity for its receptor change under hypoxic conditions? 04/11/2018

IL2's affinity for its receptor decreases under hypoxic conditions.

What post-translational modifications affect IL2's bioactivity? 02/19/2017

IL2's bioactivity is enhanced by glycosylation.

What is the role of IL2 in the differentiation of Th17 cells? 04/20/2016

IL2 promotes the differentiation of Th17 cells.

Customer Reviews (3)

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Reviews
04/13/2022

    Potent in T-cell activation.

    07/27/2018

      Suitable for cytokine assays.

      01/07/2018

        High stability.

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