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Active Recombinant Mouse Lilra5 protein, His-tagged

Cat.No. : Lilra5-264H
Product Overview : Recombinant Mouse Lilra5(Gln17-Asn248) fused with His tag at C-terminal was expressed in NS0.
  • Specification
  • Gene Information
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Description : The leukocyte immunoglobulin-like receptors (LILR) comprise a family of activating and inhibitory type immunoreceptors whose genes are located in the same locus that encodes killer cell Ig-like receptors (KIRs). Mouse LILRC1 (leukocyte immunoglobulin-like receptor C1), also known as LILRA5, ILT11, LIR-9, and CD85f, consists of a 227 amino acid (aa) extracellular domain (ECD), a 21 aa transmembrane segment, and a 10 aa cytoplasmic tail. The ECD contains two Ig-like domains, and the transmembrane segment contains a positively charged aspartic acid residue which may mediate its association with the signaling molecule, FcR common gamma chain. Within the ECD, mouse LILRC1/LILRA5 shares 56% and 85% aa sequence identity with human and rat LILRA5, respectively. LILRA5 is expressed by monocytes, macrophages, and neutrophils. It is found as an approximately 40 kDa molecule on the cell surface, while a soluble 25 kDa form can be released into the synovial fluid of rheumatoid arthritis patients. Cross-linking of LILRA5 on monocytes induces the expression of pro-inflammatory cytokines (IL-1 beta, IL-6, TNF-alpha) as well as the anti-inflammatory IL-10. R&D Systems in-house testing indicates that LILRC1/LILRA5 binds to Angiopoietin-like 7, consistent with the demonstrated functional interactions between other members of these protein families.
Source : Mammalian cells
Species : Mouse
Tag : His
Predicted N Terminal : No results obtained. Gln17 inferred from enzymatic pyroglutamate treatment revealing Glu18
Form : Lyophilized from a 0.2 μm filtered solution in PBS and NaCl.
Bio-activity : Measured by its binding ability in a functional ELISA. When Recombinant Mouse LILRC1 is coated at 2 µg/mL, Recombinant Human Angiopoietin-like Protein 7/ANGPTL7 binds with an ED50 = 60-360 ng/mL.
Molecular Mass : Predicted Molecular Mass: 27 kDa
SDS-PAGE: 36-50 kDa, reducing conditions
Endotoxin : <0.1 EU per 1 μg of the protein by the LAL method.
Purity : >95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Storage : Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70 centigrade as supplied.
1 month, 2 to 8 centigrade under sterile conditions after reconstitution.
3 months, -20 to -70 centigrade under sterile conditions after reconstitution.
Reconstitution : Reconstitute at 250 μg/mL in PBS.
Gene Name : Lilra5 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5 [ Mus musculus ]
Official Symbol : Lilra5
Synonyms : LILRA5; leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5; leukocyte immunoglobulin-like receptor; Gm4878; Lilrc1; EG232801; E030017K20;
Gene ID : 232801
mRNA Refseq : NM_001081239
Protein Refseq : NP_001074708

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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