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Recombinant Mouse Muc1 protein, His/GST-tagged

Cat.No. : Muc1-106M
Product Overview : Recombinant Mouse Muc1(Ser410~Ala525) fused with His/GST tag at the N-terminus was expressed in E. coli.
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Source : E. coli
Species : Mouse
Tag : His/GST
Form : Supplied as lyophilized form in PBS, pH7.4, containing 5% trehalose, 0.01% sarcosyl.
Molecular Mass : Predicted Molecular Mass: 45.0kDa
Protein length : Ser410~Ala525
AA Sequence : The target protein is fused with two N-terminal Tags, His-tag and GST-tag, its sequence is listed below.MSPILGYWKI KGLVQPTRLL LEYLEEKYEE HLYERDEGDK WRNKKFELGL EFPNLPYYID GDVKLTQSMA IIRYIADKHN MLGGCPKERA EISMLEGAVL DIRYGVSRIA YSKDFETLKV DFLSKLPEML KMFEDRLCHK TYLNGDHVTH PDFMLYDALD VVLYMDPMCL DAFPKLVCFK KRIEAIPQID KYLKSSKYIA WPLQGWQATF GGGDHPPKSD GSTSGSGHHH HHHSAGLVPR GSTAIGMKET AAAKFERQHM DSPDLGTLEV LFQGPLGSEF- S PQLSVGVSFF FLSFYIQNHP FNSSLEDPSS NYYQELKRNI SGLFLQIFNG DFLGISSIKF RSGSVVVEST VVFREGTFSA SDVKSQLIQH KKEADDYNLT ISEVKVNEMQ FPPSA
Endotoxin : <1.0EU per 1µg (determined by the LAL method)
Purity : >95%
Applications : SDS-PAGE; WB; ELISA; IP.
Storage : Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
Reconstitution : Reconstitute in sterile PBS, pH7.2-pH7.4.
Gene Name : Muc1 mucin 1, transmembrane [ Mus musculus ]
Official Symbol : Muc1
Synonyms : MUC1; mucin 1, transmembrane; mucin-1; episialin; EMA; CD227; Muc-1;
Gene ID : 17829
mRNA Refseq : NM_013605
Protein Refseq : NP_038633
UniProt ID : Q02496
Chromosome Location : 3 F1; 3 39.02 cM
Pathway : IL-7 Signaling Pathway, organism-specific biosystem; T Cell Receptor Signaling Pathway, organism-specific biosystem;
Function : RNA polymerase II core promoter proximal region sequence-specific DNA binding; p53 binding; transcription cofactor activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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What are the structural characteristics of the MUC1 protein? 11/12/2019

The MUC1 protein consists of a short extracellular region, a transmembrane region, and a long intracellular region. The extracellular region is rich in sugar chains, which make the MUC1 protein adherent.

What is the role of the MUC1 protein in cancer? 10/16/2019

In cancer, the expression of the MUC1 protein usually increases abnormally and changes in glycosylation occur. This can affect cell adhesion, proliferation, and invasion, promoting the spread and metastasis of cancer cells.

Is the MUC1 protein involved in the immune system? 09/02/2019

Yes, the MUC1 protein is closely related to the immune system. In some cases, abnormal expression of the MUC1 protein may interfere with the function of immune cells, thereby reducing the immune response.

In which diseases is MUC1 involved in the diagnosis and treatment? 08/17/2019

MUC1 protein is overexpressed in many types of cancer, including breast, stomach, ovarian, and others. Therefore, the MUC1 protein can be a potential target for cancer diagnosis and treatment.

What are the main physiological functions of MUC1 protein? 06/22/2019

The MUC1 protein mainly plays the role of protecting and lubricating the mucosal surface. It prevents bacteria and other pathogens from entering our body, while also helping to maintain cell-to-cell adhesion.

Is the MUC1 protein associated with other diseases? 06/01/2019

MUC1 protein may be associated with a number of other diseases, such as lung infections and inflammatory bowel disease. However, the research related to cancer is more extensive and in-depth.

Customer Reviews (3)

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Reviews
03/11/2022

    It is suitable for crystallography research and has good crystallinity.

    02/04/2022

      Target immune responses can be successfully induced.

      06/04/2019

        Enzymatic experiments showed that the catalytic efficiency was high

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