Recombinant Mouse Muc2 protein, His-tagged
Cat.No. : | Muc2-690M |
Product Overview : | Recombinant Mouse Muc2 aa. (Asn652~Glu735 (Accession# Q80Z19)) fused with N-terminal His tag was produced in E. coli cells. |
- Specification
- Gene Information
- Related Products
Source : | E. coli |
Species : | Mouse |
Tag : | His |
Form : | Freeze-dried powder |
Molecular Mass : | Predicted Molecular Mass: 10.8kDa |
Protein length : | Asn652~Glu735 (Accession# Q80Z19) |
Endotoxin : | <1.0EU per 1µg (determined by the LAL method) |
Purity : | >95% |
Characteristic : | The isoelectric point is 6.1. |
Applications : | SDS-PAGE; WB; ELISA; IP |
Stability : | The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition. |
Storage : | Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months. |
Storage buffer : | Supplied as lyophilized form in PBS, pH7.4, containing 5% trehalose, 0.01% sarcosyl. |
Reconstitution : | Reconstitute in sterile PBS, pH7.2-pH7.4. |
Gene Name : | Muc2 mucin 2 [ Mus musculus (house mouse) ] |
Official Symbol : | Muc2 |
Synonyms : | Muc2; mucin 2; MCM; wnn; 2010015E03Rik; mucin-2; colonic mucin; secreted gel-forming mucin |
Gene ID : | 17831 |
mRNA Refseq : | NM_023566.3 |
Protein Refseq : | NP_076055.3 |
UniProt ID : | Q80Z19 |
Products Types
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MUC2-1466H | Recombinant Human MUC2 Protein (36-240 aa), His-tagged | +Inquiry |
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◆ Native Protein | ||
MUC2-28P | Native Pig Mucin 2 (MUC2) Protein | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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- Q&As
- Reviews
Q&As (6)
Ask a questionThe transcriptional regulation of MUC2 protein is regulated by a variety of signaling pathways and transcription factors, including methylation modification in the MUC2 promoter region, and regulation of transcription factors GATA4 and KLF4.
Yes, mutations in the MUC2 protein have been found to be associated with hereditary myxous enteropathy (HM), a rare intestinal disease caused primarily by mutations in the MUC2 protein that result in loss of function of the mucus layer.
MUC2 protein is involved in intestinal immune regulation by influencing intestinal microbes, regulating inflammatory response and antigen presentation, helping to maintain intestinal immune balance.
The shear variant of the MUC2 protein may have an important impact on its mucus layer formation and stability. Different shear variants may affect their adhesion and resistance to degradation.
Abnormal expression and functional defects of the MUC2 protein may lead to increased retention of microorganisms and harmful substances in the intestine, triggering intestinal inflammatory responses such as intestinal mucosal inflammation and destruction of the mucus layer.
By forming a mucus layer, MUC2 protein provides a protective barrier to the gut against harmful microorganisms, toxins and other external irritants from entering the intestinal mucosa.
Customer Reviews (3)
Write a reviewIt was observed that the expression level was high enough to meet the experimental requirements.
The use of this protein found high purity and no significant impurities.
Relatively active and able to efficiently perform the required biological activity experiments.
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