Recombinant Mouse Notch1 protein, Fc-tagged
Cat.No. : | Notch1-423M |
Product Overview : | Recombinant Mouse Notch1(Met 1-Gln 526) fused with Fc region of human IgG1 at C-terminal was expressed in CHO. |
- Specification
- Gene Information
- Related Products
Source : | CHO |
Species : | Mouse |
Tag : | Fc |
Predicted N Terminal : | Ala 19 |
Form : | Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. |
Molecular Mass : | The recombinant mouse Notch1 consists 749 amino acids and predicts a molecular mass of 80.6 kDa. |
Protein length : | Met1-Gln526 |
Endotoxin : | < 1.0 EU per μg protein as determined by the LAL method. |
Purity : | > 90 % as determined by SDS-PAGE. |
Stability : | Samples are stable for up to twelve months from date of receipt at -70 centigrade |
Storage : | Store it under sterile conditions at -20 centigrade to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Reconstitution : | A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information. |
Shipping : | In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise. |
Gene Name : | Notch1 Notch gene homolog 1 (Drosophila) [ Mus musculus ] |
Official Symbol : | Notch1 |
Synonyms : | NOTCH1; Notch gene homolog 1 (Drosophila); neurogenic locus notch homolog protein 1; mT14; p300; Motch A; notch 1; major type A protein; transmembrane receptor Notch1; N1; Mis6; Tan1; lin-12; 9930111A19Rik; |
Gene ID : | 18128 |
mRNA Refseq : | NM_008714 |
Protein Refseq : | NP_032740 |
UniProt ID : | Q01705 |
Chromosome Location : | 2 A3; 2 18.91 cM |
Pathway : | Activated NOTCH1 Transmits Signal to the Nucleus, organism-specific biosystem; Delta-Notch Signaling Pathway, organism-specific biosystem; Developmental Biology, organism-specific biosystem; Dorso-ventral axis formation, organism-specific biosystem; Dorso-ventral axis formation, conserved biosystem; Gene ex |
Function : | chromatin DNA binding; chromatin binding; protein binding; receptor activity; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; |
Products Types
◆ Recombinant Protein | ||
NOTCH1-127H | Recombinant Human NOTCH1 Protein, His (Fc)-Avi-tagged | +Inquiry |
NOTCH1-5996H | Recombinant Human NOTCH1 Protein, GST-tagged | +Inquiry |
Notch1-13R | Recombinant Rat Notch1 Protein, His (Fc)-Avi-tagged | +Inquiry |
NOTCH1-2498H | Recombinant Human NOTCH1 Protein, His-tagged | +Inquiry |
NOTCH1-461H | Recombinant Human NOTCH1 Protein (Ala19-Gln526), HIgG1 Fc-tagged | +Inquiry |
◆ Lysates | ||
NOTCH1-469MCL | Recombinant Mouse NOTCH1 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionNOTCH1 contributes to the regulation of embryonic development and tissue homeostasis by influencing cell differentiation and proliferation.
The ligands or interacting partners of NOTCH1 include Delta-like 1 (DLL1), Delta-like 3 (DLL3), Delta-like 4 (DLL4), Jagged 1, and Jagged 2, regulating its activation.
Neurogenic locus notch homolog protein 1 (NOTCH1) functions in cellular processes, primarily playing a role in the Notch signaling pathway.
Dysregulation or abnormal expression of NOTCH1 is associated with conditions such as cancer, cardiovascular diseases, and developmental disorders.
NOTCH1 is predominantly localized on the cell membrane, where it undergoes proteolytic cleavage upon activation.
There are potential therapeutic implications related to NOTCH1 in diseases involving Notch signaling, making it a target for drug development.
NOTCH1 participates in the Notch signaling pathway by interacting with ligands such as Delta and Jagged, influencing cell fate determination.
Customer Reviews (3)
Write a reviewContinuous access to up-to-date training materials ensured that our team remained well-versed in the product's capabilities.
The product's evolution in response to user feedback showcased a dedication to meeting the evolving needs of researchers.
The product's compatibility with open science practices positively influenced our decision to adopt it for our experiments.
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