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Recombinant Mouse Notch1 protein, Fc-tagged

Cat.No. : Notch1-423M
Product Overview : Recombinant Mouse Notch1(Met 1-Gln 526) fused with Fc region of human IgG1 at C-terminal was expressed in CHO.
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  • Gene Information
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Source : CHO
Species : Mouse
Tag : Fc
Predicted N Terminal : Ala 19
Form : Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization.
Molecular Mass : The recombinant mouse Notch1 consists 749 amino acids and predicts a molecular mass of 80.6 kDa.
Protein length : Met1-Gln526
Endotoxin : < 1.0 EU per μg protein as determined by the LAL method.
Purity : > 90 % as determined by SDS-PAGE.
Stability : Samples are stable for up to twelve months from date of receipt at -70 centigrade
Storage : Store it under sterile conditions at -20 centigrade to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution : A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
Shipping : In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Gene Name : Notch1 Notch gene homolog 1 (Drosophila) [ Mus musculus ]
Official Symbol : Notch1
Synonyms : NOTCH1; Notch gene homolog 1 (Drosophila); neurogenic locus notch homolog protein 1; mT14; p300; Motch A; notch 1; major type A protein; transmembrane receptor Notch1; N1; Mis6; Tan1; lin-12; 9930111A19Rik;
Gene ID : 18128
mRNA Refseq : NM_008714
Protein Refseq : NP_032740
UniProt ID : Q01705
Chromosome Location : 2 A3; 2 18.91 cM
Pathway : Activated NOTCH1 Transmits Signal to the Nucleus, organism-specific biosystem; Delta-Notch Signaling Pathway, organism-specific biosystem; Developmental Biology, organism-specific biosystem; Dorso-ventral axis formation, organism-specific biosystem; Dorso-ventral axis formation, conserved biosystem; Gene expression, organism-specific biosystem; Generic Transcription Pathway, organism-specific biosystem;
Function : chromatin DNA binding; chromatin binding; protein binding; receptor activity; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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How does NOTCH1 contribute to the regulation of embryonic development and tissue homeostasis? 09/22/2022

NOTCH1 contributes to the regulation of embryonic development and tissue homeostasis by influencing cell differentiation and proliferation.

What are the ligands or interacting partners of NOTCH1, and how do they regulate its activation? 09/22/2021

The ligands or interacting partners of NOTCH1 include Delta-like 1 (DLL1), Delta-like 3 (DLL3), Delta-like 4 (DLL4), Jagged 1, and Jagged 2, regulating its activation.

What is the primary function of Neurogenic locus notch homolog protein 1 (NOTCH1) in cellular processes and signaling? 06/02/2021

Neurogenic locus notch homolog protein 1 (NOTCH1) functions in cellular processes, primarily playing a role in the Notch signaling pathway.

What diseases or conditions are associated with dysregulation or abnormal expression of NOTCH1? 05/12/2021

Dysregulation or abnormal expression of NOTCH1 is associated with conditions such as cancer, cardiovascular diseases, and developmental disorders.

In which cellular compartments is NOTCH1 predominantly localized? 02/24/2018

NOTCH1 is predominantly localized on the cell membrane, where it undergoes proteolytic cleavage upon activation.

Are there therapeutic implications or potential targets related to NOTCH1 in diseases involving Notch signaling? 07/09/2017

There are potential therapeutic implications related to NOTCH1 in diseases involving Notch signaling, making it a target for drug development.

How does NOTCH1 participate in the Notch signaling pathway, and what is its role in cell fate determination? 09/12/2016

NOTCH1 participates in the Notch signaling pathway by interacting with ligands such as Delta and Jagged, influencing cell fate determination.

Customer Reviews (3)

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Reviews
01/24/2021

    Continuous access to up-to-date training materials ensured that our team remained well-versed in the product's capabilities.

    05/09/2017

      The product's evolution in response to user feedback showcased a dedication to meeting the evolving needs of researchers.

      11/04/2016

        The product's compatibility with open science practices positively influenced our decision to adopt it for our experiments.

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