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Recombinant Mouse PDGFB Protein

Cat.No. : PDGFB-12568M
Product Overview : Recombinant Mouse PDGFB full length or partial length protein was expressed.
  • Specification
  • Gene Information
  • Related Products
Source : Mammalian Cells
Species : Mouse
Tag : His
Form : Liquid or lyophilized powder
Endotoxin : < 1.0 EU per μg of the protein as determined by the LAL method.
Purity : >80%
Notes : This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
Storage : Store it at +4 ºC for short term. For long term storage, store it at -20 ºC~-80 ºC.
Storage Buffer : PBS buffer
Gene Name : Pdgfb platelet derived growth factor, B polypeptide [ Mus musculus ]
Official Symbol : PDGFB
Gene ID : 18591
mRNA Refseq : NM_011057.3
Protein Refseq : NP_035187.2
MIM :
UniProt ID : P31240

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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In what capacity does PDGFB contribute to the intricate processes of angiogenesis and vascular remodeling? 07/26/2021

By potently stimulating the migratory and proliferative capabilities of smooth muscle cells and pericytes, PDGFB plays a pivotal role in regulating angiogenesis and orchestrating vascular remodeling events, thereby ensuring proper tissue perfusion and function.

How does PDGFB intricately contribute to the development and advancement of certain malignancies? 02/08/2020

PDGFB signaling assumes a critical role in fueling tumor growth, angiogenesis, and metastasis. PDGFB, acting through its activation of PDGFRβ, elicits a pro-tumorigenic cascade that promotes tumor cell proliferation, survival, migration, and invasion, while concurrently fueling tumor vascularization and distant metastatic spread.

In what ways is PDGFB implicated in the pathogenesis and progression of fibrotic disorders? 12/16/2018

PDGFB emerges as a significant contributor to the pathogenesis of fibrotic diseases by prompting fibroblast activation and proliferation. These dysregulated processes lead to excessive extracellular matrix deposition and subsequent tissue scarring. Furthermore, PDGFB exacerbates fibrosis through induction of myofibroblast differentiation.

What novel therapeutic avenues are being explored targeting the PDGFB/PDGFRβ signaling axis for interventional strategies? 06/28/2018

Promisingly, preclinical and clinical studies have investigated diverse approaches targeting the PDGFB/PDGFRβ signaling axis for therapeutic intervention in fibrotic disorders and certain neoplastic conditions. Inhibitors directed against PDGFB or PDGFRβ have exhibited considerable potential, effectively blocking downstream signaling cascades activated by PDGFB, thereby hampering cell proliferation and angiogenesis.

How does PDGFB actively participate in the intricate mechanisms governing wound healing and tissue regeneration? 10/22/2017

PDGFB, released by platelets and macrophages at inflammatory sites, acts as a key modulator in recruiting and activating fibroblasts. This activation not only promotes collagen synthesis but also initiates tissue remodeling, thus expediting the wound healing cascade and tissue integrity restoration.

What therapeutic strategies target PDGFB for disease treatment? 07/21/2017

Several therapeutic strategies aim to target PDGFB for disease treatment. Inhibitors of PDGFB, such as tyrosine kinase inhibitors, have been developed and used in clinical settings. These inhibitors can selectively block the activation of PDGF receptors and inhibit downstream signaling pathways, thereby suppressing excessive cell proliferation and migration. Additionally, approaches targeting PDGFB expression, such as gene therapy or RNA interference, hold promise as potential treatments for diseases associated with PDGFB dysregulation.

How does PDGFB orchestrate cellular proliferation and growth in diverse tissues and organs? 03/07/2016

PDGFB orchestrates cellular proliferative responses and drives growth by virtue of its ability to activate PDGFRβ, which in turn triggers downstream signaling cascades facilitating DNA synthesis and regulating critical cell cycle checkpoints.

Customer Reviews (3)

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Reviews
12/27/2018

    The seal of the reagent tubes is excellent, preventing evaporation and leakage.

    05/08/2018

      With its unique design and construction, the experimental reagent provides me with a fresh experimental experience.

      03/21/2016

        The stability of this reagent is exceptional, ensuring the reliability of the experiment.

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