Recombinant Mouse Stat3 protein, His-tagged
Cat.No. : | Stat3-8593M |
Product Overview : | Recombinant Mouse Stat3(Thr346~Glu552) fused with His tag at N-terminal was expressed in E. coli. |
- Specification
- Gene Information
- Related Products
Source : | E. coli |
Species : | Mouse |
Tag : | His |
Form : | Supplied as lyophilized form in PBS,pH7.4, containing 5% sucrose, 0.01% sarcosyl. |
Molecular Mass : | 24.8kDa |
Protein length : | Thr346~Glu552 |
AA Sequence : | MGHHHHHHSG SEF- TTKVR LLVKFPELNY QLKIKVCIDK DSGDVAALRG SRKFNILGTN TKVMNMEESN NGSLSAEFKH LTLREQRCGN GGRANCDASL IVTEELHLIT FETEVYHQGL KIDLETHSLP VVVISNICQM PNAWASILWY NMLTNNPKNV NFFTKPPIGT WDQVAEVLSW QFSSTTKRGL SIEQLTTLAE KLLGPGVNYS GCQITWAKFC KE |
Endotoxin : | <1.0EU per 1ug (determined by the LAL method) |
Purity : | > 95% |
Storage : | Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months. |
Reconstitution : | Reconstitute in sterile PBS, pH7.2-pH7.4. |
Gene Name : | Stat3 signal transducer and activator of transcription 3 [ Mus musculus ] |
Official Symbol : | Stat3 |
Synonyms : | STAT3; signal transducer and activator of transcription 3; acute phase response factor; acute-phase response factor; Aprf; AW109958; 1110034C02Rik; |
Gene ID : | 20848 |
mRNA Refseq : | NM_011486 |
Protein Refseq : | NP_035616 |
UniProt ID : | Q6GU23 |
Chromosome Location : | 11 D; 11 63.82 cM |
Pathway : | Acute myeloid leukemia, organism-specific biosystem; Acute myeloid leukemia, conserved biosystem; Adipocytokine signaling pathway, organism-specific biosystem; Adipocytokine signaling pathway, conserved biosystem; Adipogenesis, organism-specific biosystem; Androgen Receptor Signaling Pathway, organism-specific biosystem; B Cell Receptor Signaling Pathway, organism-specific biosystem; |
Function : | CCR5 chemokine receptor binding; DNA binding; DNA binding; calcium ion binding; glucocorticoid receptor binding; ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity; protein binding; protein dimerization activity; protein kinase binding; sequence-specific DNA binding; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; signal transducer activity; transcription factor binding; transcription regulatory region DNA binding; |
Products Types
◆ Recombinant Protein | ||
STAT3-8786M | Recombinant Mouse STAT3 Protein, His (Fc)-Avi-tagged | +Inquiry |
STAT3-07H | Recombinant Human STAT3 Protein, His-tagged | +Inquiry |
STAT3-4148H | Recombinant Human STAT3 Protein, His (Fc)-Avi-tagged | +Inquiry |
Stat3-6170M | Recombinant Mouse Stat3 Protein, Myc/DDK-tagged | +Inquiry |
Stat3-2107R | Recombinant Rat Stat3 Protein, His-tagged | +Inquiry |
◆ Lysates | ||
STAT3-1418HCL | Recombinant Human STAT3 293 Cell Lysate | +Inquiry |
STAT3-1417HCL | Recombinant Human STAT3 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
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Q&As (7)
Ask a questionYes, there are several inhibitors targeting STAT3, including Stattic, S3I-201, and OPB-31121, which are being explored for their therapeutic potential in cancer and other diseases.
Yes, activated STAT3 can promote cell proliferation and survival by inducing the expression of genes like cyclin D1 and Bcl-xL.
STAT3 can contribute to oncogenesis by promoting cell proliferation, survival, angiogenesis, and immune evasion, and by suppressing apoptosis in various cancer types.
Activation of STAT3 can be detected using Western blotting with phospho-specific antibodies that recognize the tyrosine-phosphorylated form of STAT3.
STAT3 can interact with other signaling pathways such as the MAPK, PI3K/AKT, and NF-κB pathways, leading to integrated cellular responses.
The primary upstream activators of STAT3 are cytokines and growth factors, especially those that signal through the Janus kinase (JAK) family, such as IL-6 and EGF.
STAT3 plays a crucial role in the differentiation of Th17 cells, a subset of CD4+ T cells, and is also involved in the function of myeloid-derived suppressor cells (MDSCs) and regulatory T cells, influencing immune responses.
Customer Reviews (3)
Write a reviewProtein worked well in assay.
Fast shipping, great customer service.
Excellent purity, highly recommend.
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