Recombinant Rat Agt protein, His/S-tagged
Cat.No. : | Agt-254R |
Product Overview : | Recombinant Rat Agt fused with His/S tag was expressed in E. coli. |
- Specification
- Gene Information
- Related Products
Description : | Angiotensinogen, also known as AGT and SerpinA8, is a member of the serpin family. It is an α-2-globulin that is produced constitutively and released into the circulation mainly by the liver. Angiotensinogen is a essential component of the renin-angiotensin system (RAS) and a potent regulator of blood pressure. Angiotensinogen can be schematically considered to consist of a combination of an angiotensin I (Ang I) function, located at the N-terminal end, and the presence of a serpin (serine protease inhibitor) structure at the opposite end. Angiotensinogen is cleaved into three chains: Angiotensin-1 (Ang I), Angiotensin-2 (Ang II), and Angiotensin-3 (Ang III). Angiotensin-1 is a substrate of ACE (angiotensin converting enzyme) that removes a dipeptide to yield the physiologically active peptide angiotensin-2. Angiotensin-1 and angiotensin-2 can be further processed to generate angiotensin-3, angiotensin-4. Angiotensin 1-7 is cleaved from angiotensin-2 by ACE2. Angiotensin-2 acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system. Defects in AGT are associated with susceptibility to essential hypertension and renal tubular dysgenesis (RTD). Several serpins (antithrombin, maspin, pigment epithelial-derived factor, and kallistatin) have been recently shown to exert an antiangiogenic activity, suggesting a common mechanism of endothelial cell proliferation and migration. Angiotensinogen/AGT and its renin-cleaved product, des(Ang I)AGT, are also angiogenesis inhibitors, both in vitro and in vivo at concentrations within the range of those observed in plasma. The Angiotensinogen products, that is angiotensin II and possibly angiotensin II-related products, have been found to act locally in modulating adipose tissue growth in an autocrine/paracrine manner. The transient or chronic overexpression of angiotensinogen in adipose tissue favors lipogenesis in adipocytes and leads to a 'vicious' circle whereby adipose tissue development is further increased. |
Source : | E. coli |
Species : | Rat |
Tag : | His/S |
Form : | Lyophilized from sterile PBS, pH 7.4 |
Purity : | > 95 % as determined by SDS-PAGE |
Storage : | Store at -70 centigrade. Avoid repeated freeze/thaw cycles. |
Gene Name : | Agt angiotensinogen (serpin peptidase inhibitor, clade A, member 8) [ Rattus norvegicus ] |
Official Symbol : | Agt |
Synonyms : | AGT; angiotensinogen (serpin peptidase inhibitor, clade A, member 8); angiotensinogen; serpin A8; angiotensin II; angiotensinogen (PAT); Ang; PAT; ANRT; AngII; |
Gene ID : | 24179 |
mRNA Refseq : | NM_134432 |
Protein Refseq : | NP_602308 |
Chromosome Location : | 19q12 |
Pathway : | ACE Inhibitor Pathway, organism-specific biosystem; Adipogenesis, organism-specific biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; G alpha (q) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; GPCR ligand binding, organism-specific biosystem; Peptide ligand-binding receptors, organism-specific biosystem; |
Function : | acetyltransferase activator activity; acetyltransferase activator activity; alpha1-adrenergic receptor activity; angiotensin receptor binding; hormone activity; serine-type endopeptidase inhibitor activity; type 1 angiotensin receptor binding; type 1 angiotensin receptor binding; type 2 angiotensin receptor binding; type 2 angiotensin receptor binding; |
Products Types
◆ Recombinant Protein | ||
AGT-517H | Recombinant Human AGT Protein, MYC/DDK-tagged | +Inquiry |
Agt-01M | Recombinant Mouse Agt Protein | +Inquiry |
Agt-96M | Recombinant Mouse Agt Protein, His-tagged | +Inquiry |
AGT-221R | Recombinant Rat AGT Protein, His (Fc)-Avi-tagged | +Inquiry |
Agt-554M | Recombinant Mouse Agt Protein, MYC/DDK-tagged | +Inquiry |
◆ Native Protein | ||
AGT-152H | Native Human Angiotensinogen | +Inquiry |
◆ Lysates | ||
AGT-2575HCL | Recombinant Human AGT cell lysate | +Inquiry |
AGT-1842MCL | Recombinant Mouse AGT cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
- Reviews
Q&As (10)
Ask a questionAGT is produced and released by the kidneys, and it plays a role in regulating renal blood flow and glomerular filtration rate, thereby impacting overall kidney function.
AGT is the precursor molecule for angiotensin peptides, including angiotensin I and angiotensin II, which are key regulators of blood pressure, fluid balance, and cardiovascular homeostasis.
AGT-derived angiotensin II plays a critical role in vasoconstriction, sodium reabsorption, and the regulation of aldosterone secretion, all of which influence blood pressure.
AGT and the renin-angiotensin system have been implicated in the central regulation of blood pressure, fluid balance, and neuroendocrine functions.
AGT is cleaved by the enzyme renin to generate angiotensin I, which is subsequently converted to angiotensin II by the enzyme angiotensin-converting enzyme (ACE).
AGT expression is regulated by various factors, including hormones (such as aldosterone and glucocorticoids), cytokines, and environmental stimuli.
AGT and its derivatives, such as angiotensin II, can promote inflammation and tissue remodeling through interactions with receptors and signaling pathways.
Experimental techniques used to study AGT include molecular biology approaches, gene expression analysis, protein quantification, immunohistochemistry, and animal models.
Genetic variations in the AGT gene have been associated with an increased risk of hypertension, cardiovascular diseases, and other conditions influenced by the renin-angiotensin system.
AGT levels and the renin-angiotensin system play a role in regulating blood pressure during pregnancy, and dysregulation can contribute to disorders such as preeclampsia.
Customer Reviews (5)
Write a reviewThe proteins offering reliable results and contributing to the success of my experiments.
The customer service team was incredibly helpful and responsive to my inquiries.
The product allowed me to access high-quality reagents while staying within my budget.
The ordering process was seamless, and the company's efficient shipping ensured that I received the recombinant proteins promptly and in excellent condition.
Ask a Question for All Agt Products
Required fields are marked with *
My Review for All Agt Products
Required fields are marked with *
Inquiry Basket