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Recombinant Rat AGXT Protein

Cat.No. : AGXT-569R
Product Overview : Recombinant Rat AGXT full length or partial length protein was expressed.
  • Specification
  • Gene Information
  • Related Products
Source : Mammalian Cells
Species : Rat
Tag : His
Form : Liquid or lyophilized powder
Endotoxin : < 1.0 EU per μg of the protein as determined by the LAL method.
Purity : >80%
Notes : This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
Storage : Store it at +4 ºC for short term. For long term storage, store it at -20 ºC~-80 ºC.
Storage Buffer : PBS buffer
Gene Name : Agxt alanine-glyoxylate aminotransferase [ Rattus norvegicus ]
Official Symbol : AGXT
Gene ID : 24792
mRNA Refseq : NM_030656.2
Protein Refseq : NP_085914.2
MIM :
UniProt ID : P09139

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (10)

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Are there any known structural motifs in AGXT essential for its enzymatic activity? 02/28/2022

AGXT contains a PLP-binding domain, characteristic of aminotransferases, which is critical for its enzymatic activity and substrate specificity.

Can mutations in the AGXT gene lead to any hereditary disorders? 06/04/2021

Yes, mutations in the AGXT gene can cause primary hyperoxaluria type 1 (PH1), a rare autosomal recessive disorder characterized by the overproduction and accumulation of oxalate, resulting in severe kidney and urinary tract complications.

Can AGXT be targeted therapeutically for the treatment of kidney stones in non-PH1 patients? 01/07/2021

Targeting AGXT enzymatic activity may hold promise for developing therapies to prevent kidney stone formation in non-PH1 patients; however, further research is needed to validate this approach.

Which cellular compartment is AGXT predominantly localized in? 12/30/2020

AGXT is primarily localized in the peroxisomes, a subcellular organelle responsible for various metabolic processes, including lipid metabolism and detoxification.

Can AGXT activity be influenced by epigenetic modifications? 10/28/2020

Epigenetic modifications, such as DNA methylation or histone acetylation, could potentially regulate AGXT gene expression and activity, affecting oxalate metabolism.

How is AGXT activity regulated at the post-translational level? 03/15/2020

AGXT activity can be regulated by phosphorylation, allosteric modulation, and interaction with other proteins involved in peroxisomal metabolism.

What is the primary function of AGXT in the human body? 08/17/2019

AGXT plays a crucial role in the peroxisomal glyoxylate pathway, converting glyoxylate to glycine to prevent the accumulation of harmful oxalate, which can lead to kidney stone formation.

How does AGXT deficiency lead to hyperoxaluria in PH1 patients? 05/23/2019

In PH1 patients, AGXT deficiency impairs the conversion of glyoxylate to glycine, leading to the accumulation of glyoxylate. Excessive glyoxylate is converted to oxalate, which can form kidney stones and cause tissue damage.

Is AGXT involved in other physiological processes beyond oxalate metabolism? 12/19/2018

AGXT may participate in other cellular processes or metabolic pathways, and its broader functional roles warrant further exploration.

What is the reaction catalyzed by AGXT in the glyoxylate pathway? 11/10/2018

AGXT catalyzes the conversion of glyoxylate and L-alanine to glycine and pyruvate, utilizing PLP as a cofactor.

Customer Reviews (5)

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Reviews
03/07/2022

    The customer service was fantastic—helpful, friendly, and made the ordering process a breeze!

    02/10/2022

      The efficiency of this protein is outstanding. Saved me a lot of time!

      07/30/2021

        I never knew how much easier my work could be until I tried this protein.

        11/16/2019

          I'm so grateful for this protein – it's a game-changer for my studies!

          08/02/2018

            I can confidently say that this product is worth every penny.

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